Three-dimensional thermomechanical modelling beneath Guerrero, Mexico, and its relation to the occurrence of interplate seismic phenomena.

In this study, we investigated the relationships among the occurrence regions of megathrust earthquakes and slow earthquakes, estimated interplate temperatures, and dehydration processes at the plate interface in the subduction zone of the Cocos plate in Mexico, with a focus on the Guerrero seismic gap. For this purpose, we performed a series of 3-D thermomechanical numerical simulations of subduction based on a combination of multiple unknown model parameters. Comparing the temperature field for the optimal model with the occurrence region of the interplate seismic phenomena, the temperature along the slab surface where megathrust earthquakes tend to occur is estimated to range from 200 to 400 °C.

Towards a genetics of semantics? False memories and semantic memory organization in Williams syndrome.

Williams syndrome (WS) is a rare genetic neurodevelopmental disorder caused by microdeletion of a critical region on chromosome 7q11.23. At the cognitive level, it is usually characterized by moderate intellectual disability and deficits in visuospatial skills, while showing relative strengths in verbal skills and nonverbal reasoning.

A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Transcription factors (TFs) are key regulators of gene expression, yet many of their targets and modes of action remain unknown. In Schizosaccharomyces pombe, one-third of TFs are solely homology predicted, with few experimentally validated. We created a comprehensive library of 89 endogenously tagged S.

Clinical and Proteomic Insights into a Cytokine Release Syndrome Triggered by Tebentafusp in a Metastatic Uveal Melanoma Patient: Case Report.

Uveal melanoma is the most common primary intraocular cancer in adults; however, it remains rare. Despite its rarity, metastatic uveal melanoma poses significant treatment challenges. Tebentafusp, a T-cell receptor-bispecific molecule targeting glycoprotein 100 and CD3, has shown substantial survival benefits for HLA-A*02:01 positive patients.