EPIGENETIC CHANGES - HISTONE 3 PHOSPHORYLATION - EPITHELIAL OVARIAN TUMORS.

Histone modifications represent one of the types of epigenetic changes. Histones, undergo different types of epigenetic modifications, including the phosphorylation of serine residues. pHH3 antibodies specifically detect histon-3 protein, when phosphorylated at 10th and 28th serine residues.

MORPHOPHENOTYPIC CHARACTERISTICS OF OVARIAN SEROUS BORDERLINE TUMORS.

Borderline ovarian tumors (BOTs) represent particular challenge for diagnosis and clinical management as they are characterized with the features of both benign cystadenomas and malignant carcinomas. The aim of our study was to investigate histomorphological and immunohistochemical characteristics of ovarian serous-papillary borderline tumors, compared to serous cystadenomas and low- and high-grade serous carcinomas. Altogether, 80 formalin fixed and paraffin embedded tissue specimens, distributed in four groups, including serous cystadenoma (group I), serous BOTs (group II), Low (group III) and high (group IV) grade serous carcinomas, were investigated by standard immunohistochemistry, using antibodies against CK7 CK20, WT1, Vimentin, CDX2, CEA, ER, cyclin D1, BCL2, E-cadherin, calretinin, СA125, Ki67, P53.

BRAF ANTIBODY EXPRESSION IN DIFFERENT TYPES OF THYROID NODULAR LESIONS.

Major problems haunt the physicians who need to delineate the best management strategy for their patients with thyroid nodule is the identification of the most aggressive cases, especially among papillary thyroid cancers, which would benefit from more aggressive therapy and follow up. Beyond its strong correlation with PTC, the BRAF mutation is well described to associate with poor prognosis. The aim of our study was to identify BRAF antibody expression in different hystotypes of the thyroid nodules and assessment of it expression according to the tumor aggressiveness.

ACCURATE DIAGNOSIS OF THYROID NODULES: A REVIEW OF DIAGNOSTIC DILEMMAS ON THYROID FINE-NEEDLE ASPIRATION BIOPSIES.

FNA biopsy is well known method for the first step evaluation of thyroid nodules, it is the "gold standard" for diagnosis and surgical approach of nodular goiter. Despite the high sensitivity and specificity of the method there are grey zone in the diagnosis of thyroid nodules, mainly due to the heterogeneous group of Bethesda category AUS/FLUS. There are also some difficulties in diagnosis of PTC, especially FVPTC, even on histologic sections.

DISTRIBUTION OF THYROID PATHOLOGIES IN DIFFERENT AGE GROUPS IN GEORGIA.

We aimed to analyze the diagnostic criteria proposed by the Bethesda System for reporting thyroid Fine needle aspiration biopsy (FNAB) results. FNABs of 600 patients were performed during 1-year period (2013-2014) in Georgian hospitals (Tbilisi Cancer Center, New Hospitals, National Screening Center). Based on our clinical, ultrasound, FNAB and histology results we define how each diagnostic category of the Bethesda System is distributed among age and sex groups of the cases included in this work.