Sub-acute toxicity, antinociceptive and anti-inflammatory effects of Mucuna pruriens L. leaves in experimental rodents.

Ethnopharmacological Relevance: Mucuna pruriens L is a wild and cultivated leguminous plant which have been used as an aphrodisiac, diuretic, nerve tonic, and antiarthritic agent.

Aim: To evaluate the toxicity, antinociceptive, and anti-inflammatory activities of M. pruriens (EEMP) ethanol extract in experimental models.

Two years of COVID-19 vaccination in Nigeria: a review of the current situation of the pandemic: a literature review.

Curtailing COVID-19 outbreaks has been the major focus for many countries following the onset of the COVID-19 pandemic. Nigeria expanded its effort with the commencement of its vaccination program against COVID-19 in March 2021 after several less effective interventions as vaccine introduction was implemented. Following the introduction of the vaccines, Nigeria is expected to meet the worldwide COVID-19 eradication target of vaccinating 40% and 70% of the population, respectively, by the end of 2021 and 2022.

Toxicological evaluation of hydroethanol leaf extract of (Linn.) Juss. (Amaranthaceae) in rodents.

Objectives: Several studies have established the ethnobotanical benefits of (PL) in laboratory animals without extensive toxicological evaluation of its safety profiles. Thus, an extensive toxicological investigation of sub-chronic oral administration of the hydroethanol leaf extract of in rodents was carried out in this study.

Methods: Different groups of rats were treated orally with the extract (10, 50 and 250 mg/kg) daily for 90 consecutive days.

Toxicological evaluation of hydroethanol leaf extract of (Linn.) Juss. (Amaranthaceae) in rodents.

Objectives: Several studies have established the ethnobotanical benefits of (PL) in laboratory animals without extensive toxicological evaluation of its safety profiles. Thus, an extensive toxicological investigation of sub-chronic oral administration of the hydroethanol leaf extract of in rodents was carried out in this study.

Methods: Different groups of rats were treated orally with the extract (10, 50 and 250 mg/kg) daily for 90 consecutive days.

Atomistic simulation reveals structural mechanisms underlying D614G spike glycoprotein-enhanced fitness in SARS-COV-2.

D614G spike glycoprotein (sgp) mutation in rapidly spreading severe acute respiratory syndrome coronavirus-2 (SARS-COV-2) is associated with enhanced fitness and higher transmissibility in new cases of COVID-19 but the underlying mechanism is unknown. Here, using atomistic simulation, a plausible mechanism has been delineated. In G614 sgp but not wild type, increased D(G)614-T859 Cα-distance within 65 ns is interpreted as S1/S2 protomer dissociation.