Publications by authors named "E BENGTSSON"
Type 2 diabetes is associated with cardiovascular disease, possibly due to impaired vascular fibrous repair. Yet, the mechanisms are elusive. Here, we investigate alterations in the fibrous repair processes in type 2 diabetes atherosclerotic plaque extracellular matrix by combining multi-omics from the human Carotid Plaque Imaging Project cohort and functional studies.
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- * Electrophysiological tests showed that these Urocortin 3 neurons are influenced by both inhibitory local inputs and receive inputs from various sensory fibers, which are critical for mechanosensation.
- * Activation or inhibition of these neurons leads to observable behaviors, suggesting they play a key role in response to mechanical stimuli like scratching and specific chemical sensations.
Background: Prostate cancer (PCa) is among the most common cancers in men and its diagnosis requires the histopathological evaluation of biopsies by human experts. While several recent artificial intelligence-based (AI) approaches have reached human expert-level PCa grading, they often display significantly reduced performance on external datasets. This reduced performance can be caused by variations in sample preparation, for instance the staining protocol, section thickness, or scanner used.
View Article and Find Full Text PDFAims: The interleukin-1 receptor accessory protein (IL1RAP) is a co-receptor required for signalling through the IL-1, IL-33, and IL-36 receptors. Using a novel anti-IL1RAP-blocking antibody, we investigated the role of IL1RAP in atherosclerosis.
Methods And Results: Single-cell RNA sequencing data from human atherosclerotic plaques revealed the expression of IL1RAP and several IL1RAP-related cytokines and receptors, including IL1B and IL33.
Aims: Invariant natural killer T (iNKT) cells, a T cell subset that is CD1d-restricted and expresses a semi-invariant T cell receptor, have been proposed to contribute to dyslipidaemia-driven cardiovascular disease due to their ability to specifically recognize lipid antigens. Studies in mice have attributed pro-atherogenic properties to iNKT cells, but studies in humans investigating associations of iNKT cells with incident coronary events (CE) are lacking.
Methods And Results: Here, we used flow cytometry to enumerate circulating iNKT cells (CD3 CD1d-PBS57-Tetramer) in a case-control cohort nested within the prospective population-based Malmö Diet and Cancer Study ( = 416) to explore associations with incident first-time CE during a median follow-up of 14 years.