Publications by authors named "E B de Souza Pinto"
There is no consensus in the literature regarding the ideal protocol for obtaining and preparing cell samples for untargeted metabolomics. Nevertheless, the procedures must be carefully evaluated for proper and reliable results for each organism under study. This work proposes a novel protocol for determining intracellular metabolites in Leishmania promastigotes and is fully optimized for application in conjunction with gas chromatography-mass spectrometry platforms.
View Article and Find Full Text PDFObjectives: to verify the construct validation of an instrument for evaluating care for people living with HIV in Primary Health Care.
Methods: methodological study carried out in 2021 with 260 health professionals in Recife, PE. Validation based on the internal structure was carried out at this stage using exploratory and confirmatory factor analysis, and validity based on item response theory.
Objective: The purpose of this systematic review and meta-analysis was comparing diagnostic performance of ultrasound elastography (UE), strain UE and shear wave elastography (SWE), with magnetic resonance imaging (MRI) in differentiating benign and malignant breast lesions.
Methods: Literature search of MEDLINE, Web of Science, SCOPUS and Google Scholar was performed in June 2023. Included studies used Breast Imaging Reporting and Data System (BI-RADS) and histopathology as reference standard.
In the past decades, Chimeric Antigen Receptor (CAR)-T cell therapy has achieved remarkable success, leading to the approval of six therapeutic products for haematological malignancies. Recently, the therapeutic potential of this therapy has also been demonstrated in non-tumoral diseases. Currently, the manufacturing process to produce clinical-grade CAR-T cells is complex, time-consuming, and highly expensive.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the toxicity of lanthanum, yttrium, and cerium oxides on the soil organism Enchytraeus crypticus, focusing on survival, reproduction, avoidance behavior, and DNA integrity.
- The research finds that the bulk forms of LaO have more significant effects than their nanoparticle counterparts, while YO nanoparticles are more toxic overall, impacting reproduction and causing DNA damage at lower concentrations.
- Results indicate that the toxicity of rare earth element oxides varies based on the type of element, concentration, exposure duration, and form, underscoring the need for careful risk assessment for soil ecosystems affected by these substances.