Factors Influencing Daily Living and Ostomy Self-Care Management in Ostomates: A Mixed Methods Study.

Aim: To examine the factors affecting the ability of ostomates to perform activities of daily living and manage ostomy self-care.

Design: Mix method design.

Method: This study was undertaken through survey (descriptive and clinical characteristics form and Katz Activities of Daily Living (ADL)) for collecting the quantitative data (n = 60) and semi-structured interviews were conducted with patients unable to perform ostomy self-care for collecting qualitative data (n = 12) between January 2023 and December 2023.

Exocrine pancreatic insufficiency as an unusual extrarenal manifestation of proximal renal tubular acidosis associated with a novel SLC4A4 mutation.

Autosomal recessive proximal renal tubular acidosis (AR-pRTA) with ocular abnormalities is a rare syndrome caused by variants in the SLC4A4 gene, which encodes Na/HCO3 cotransporter (NBCe1). The syndrome primarily affects the kidneys, but also causes extra-renal manifestations. Pancreatic type NBCe1 is located at the basolateral membrane of the pancreatic ductal cells and together with CFTR chloride channel, it is involved in bicarbonate secretion.

The SPICE Modeling of a Radiation Sensor Based on a MOSFET with a Dielectric HfO/SiO Double-Layer.

We report on a procedure for extracting the SPICE model parameters of a RADFET sensor with a dielectric HfO/SiO double-layer. RADFETs, traditionally fabricated as PMOS transistors with SiO, are enhanced by incorporating high-k dielectric materials such as HfO to reduce oxide thickness in modern radiation sensors. The fabrication steps of the sensor are outlined, and model parameters, including the threshold voltage and transconductance, are extracted based on experimental data.

Facile synthesis of unknown 6,7-dihydrofuro[3,4-]pyridines and 3,4-diaryloylpyridines from -homopropargylic β-enaminones.

In this paper, we have uncovered a new reaction of -homopropargylic β-enaminones, -(4-phenyl-3-butynyl)-β-enaminones. When subjected to a reaction with excess molecular iodine or -iodosuccinimide in the presence of cesium carbonate, -homopropargylic β-enaminones afford 6,7-dihydrofuro[3,4-]pyridines in low to moderate yields. The generation of two new C/O-C bonds during the reaction leads to the construction of unknown heterobicyclic 5,6-fused ring systems.

FABP4 as a therapeutic host target controlling SARS-CoV-2 infection.

Host metabolic fitness is a critical determinant of infectious disease outcomes. Obesity, aging, and other related metabolic disorders are recognized as high-risk disease modifiers for respiratory infections, including coronavirus infections, though the underlying mechanisms remain unknown. Our study highlights fatty acid-binding protein 4 (FABP4), a key regulator of metabolic dysfunction and inflammation, as a modulator of SARS-CoV-2 pathogenesis, correlating strongly with disease severity in COVID-19 patients.