[Methodological approaches to experimental investigation of drugs for the prophylaxis and treatment of prostate gland disorders].

New methodological approaches to preclinical study of the efficiency of potential prostatotropic drugs are suggested on the basis of original research and published data. An algorithm is proposed to investigate specific activity and safety of potential drugs for the prevention and treatment of prostate disorders.

[Methodological approaches to the experimental investigation of dermotropic drugs].

Methodological approaches to preclinical evaluation of the efficiency of potential dermotropic preparations are proposed on the basis of original investigations and an analysis of published data. At the first stage of the preclinical investigation of preparations for external application, it is necessary to estimate their acute toxicity, allergenic activity, and local irritation effect in addition to studying the specific activity.

[The specific features of bacterial isolation and drug resistance of Mycobacteria in extrapulmonary tuberculosis].

The reduced viability and enzymatic activity of the pathogen from the foci of extrapulmonary tuberculosis are twice more frequently than those in pulmonary tuberculosis. The isolation of mycobacterial L-forms and the use of polymerase chain reaction significantly enhance the efficiency of the etiological diagnosis of extrapulmonary tuberculosis. There are extremely poor trends for drug resistance to develop in mycobacteria, in 2005 the rate of which was 92.

[Treatment results in endometrial cancer in patients of reproductive age].

195 reproductive patients (23-29 years--6.2%, 40-45 years--57.4%) were treated for endometrial carcinoma.

[Methodologic and organizational principles of selective screening for cervical, endometrial and ovarian carcinoma].

Data are presented on screening for cervical (CC), endometrial (UC) and ovarian (OC) carcinoma carried out in the Republic of Belarus as well as a discussion of logistic and methodologic aspects of the problem. Local "centers for prevention and early diagnosis of reproductive organ tumors" form the backbone of the national system. They operate on the basis of the existing guidelines about such matters as screening staging, sites, examination procedures used at each stage and suitable distribution of medical personnel (obstetricians, doctor's assistants, gynecologists).