[Trends of tuberculosis morbidity and mortality in Russia in 2005].

The most informative indices; such as tuberculosis morbidity and mortality, were used to assess the tuberculosis epidemiological situation in Russia in 2005. Analysis of the rates of tuberculosis morbidity and mortality showed that the epidemic situation associated with tuberculosis remained to be of strain in Russia in 2005. This is evidenced by high tuberculosis morbidity and mortality rates and their increase.

[Possible connection between the level of heterozygosity of biochemical gene markers in patients with lung diseases].

The comparative heterozygosity level was estimated in patients suffering from squamous epithelial lung cancer (SELC) and in patients with chronic pneumonia with bronchiectases. To estimate heterozygosity, seven loci, reflecting normal diversity in human populations, were used (HP, TF, GC, PI, GL01, ACP1, PGM1). SELC patients with an uncomplicated postoperative period were distinguished by an increase in the level of observed heterozygosity (Hzero = 0.

[Effect of hereditary factors on tolerance for surgical treatment in patients with lung cancer].

Genetic polymorphism at 10 independent loci (ABO, RH, HP, GC, PI, TF, ACP1, PGM1, GLO1, and PTC) was studied in male patients with lung squamous cell carcinoma. These patients were divided into two groups, depending on their tolerance for surgical intervention and on the postoperative course: (1) patients with an uneventful postoperative period and (2) patients with postoperative complications. The genetic structure of the combined sample at the loci studied did not differ from that of the control group consisting of health people (population control).

[Role pf genetic and other biomarkers in the prognostication of postoperative course in patients with lung cancer].

Relationships between genetic polymorphisms (ABO, RH, HP, TF, GC, Pi, ACP1, PGM1, GLO1, PTC) and some clinical, biochemical, and functional parameters were studied in patients with epidermoid carcinoma of the lung who were divided into 2 groups: those with uncomplicated and complicated postoperative courses of the disease. They were found to be different in the two groups. The values of ESR, albumin, lymphocytes, vital capacity, and RQ are the most distinctive signs that differentiate the patient groups.