Safety and immunogenicity of meningococcal ACWY CRM197-conjugate vaccine in children, adolescents and adults in Russia.

Neisseria meningitidis is the leading cause of bacterial invasive infections in people aged <15 years in the Russian Federation. The aim of this phase III, multicenter, open-label study was to assess the immunogenicity and safety of the quadrivalent meningococcal CRM197-conjugate vaccine MenACWY when administered to healthy Russian subjects aged 2 years and above. A total of 197 subjects were immunized with a single dose of the vaccine, and serogroup-specific serum bactericidal activity was measured pre and 1-month post-vaccination with human complement (hSBA) serum titers.

[Moexipril influence on quality of life in postmenopausal women with arterial hypertension].

Aim: To evaluate a hypotensive effect and metabolic neutrality and safety of ACE inhibitor moexipril in postmenopausal women with arterial hypertension (AH), influence on quality of life.

Material And Methods: Thirty two hypertensive postmenopausal women (age 63.1 +/- 0.

[Calcium metabolism in arterial hypertension. II. Changes in thrombocyte sensitivity to verapamil].

Verapamil produced dose-dependent inhibition of ADP- and TAF-induced increase in thrombocyte calcium concentration in hypertensive patients. Sensitivity to verapamil tested by EC50-half-maximal inhibition of responses to hormones can be weakened in vitro by adrenalin and strengthened by papaverin. Thrombocytes of hypertensive patients were individually sensitive to combination of papaverin and verapamil.

[Changes in the characteristics of glucocorticoid hormone binding in human peripheral blood lymphocytes during myocardial infarct].

Competitive binding was used to determine the number of binding sites to glucocorticoid hormones in peripheral blood leukocytes of normal subjects, patients with unstable angina pectoris and patients with myocardial infarction. A sharp (2-3-fold) increase in the number of binding sites was observed in patients with myocardial infarction during the first 24 hours after the onset of the disease.