Targeted CRISPR regulation of ZNF865 enhances stem cell cartilage deposition, tissue maturation rates, and mechanical properties in engineered intervertebral discs.

Cell and tissue engineering based approaches have garnered significant interest for treating intervertebral disc degeneration and associated low back pain due to the substantial limitations of currently available clinical treatments. Herein we present a clustered regularly interspaced short palindromic repeats (CRISPR)-guided gene modulation strategy to improve the therapeutic potential of cell and tissue engineering therapies for treating intervertebral disc disease. Recently, we discovered a zinc finger (ZNF) protein, ZNF865 (BLST), which is associated with no in-depth publications and has not been functionally characterized.

Implementation of allied health careers for the deaf at the Rochester Institute of Technology.

The National Technical Institute for the Deaf (NTID) at the Rochester Institute of Technology (RIT) offers allied health programs for the deaf under the auspices of the School of Health Related Professions at RIT. The educational goals of NTID are achieved through use of a unique curriculum process model. This model analyzes the need/justification of new curricular options, outlines developmental and design stages of the curriculum and ensures the continued viability of the curriculum through ongoing maintenance and evaluation.