The dopamine D2 receptor (D2) has been implicated in attention-deficit hyperactive disorder (ADHD) and aging. Two isoforms of D2 have been identified, termed D2L (long form) and D2S (short form). In this study, we investigated the role of D2L in offensive aggression, using mice lacking the dopamine D2L receptor (D2L-/-) as a model system and the resident-intruder test.
View Article and Find Full Text PDFThe dopamine D2 receptor (D2) system has been implicated in several neurological and psychiatric disorders, such as schizophrenia and Parkinson's disease. There are two isoforms of the D2 receptor: the long form (D2L) and the short form (D2S). The two isoforms are generated by alternative splicing of the same gene and differ only by 29 amino acids in their protein structures.
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