What's been tried: a curated catalogue of efforts to improve access to general practice.

Background: Although increasing numbers of appointments are being provided, public satisfaction with access to UK general practice is declining. Previous attempts to improve access have not been systematically collated.

Aim: We aimed to identify interventions to improve access to general practice in the UK, to organise these interventions into thematic categories, and to identify which aspects of access are targeted.

Public Health.

Background: Some evidence supports an association between traumatic brain injury (TBI) and greater risk of dementia, but the role of cognitive resilience in this association is poorly understood.

Method: 2,050 participants from the Framingham Heart Study Offspring cohort who were aged ≥60 year and had a plasma total tau (t-tau) measure at Exam 8 (2005-2008), and a neuropsychological (NP) exam visit within five years were included. Plasma t-tau was measured using the Simoa assay (Quanterix).

Public Health.

Background: Although traumatic brain injury (TBI) is known to be associated with short term mortality, its effects on long-term mortality remain less clear. TBI is also a well-known risk factor for dementia. We hypothesized that TBI would be associated with long-term mortality, particularly dementia-related mortality.

Virtual Care Appointments and Experience Among Older Rural Patients with Chronic Conditions in New South Wales: An Analysis of Existing Survey Data.

This retrospective, descriptive study, conducted in 2024, analysed Virtual Care Survey (2020-2022) data of patients' self-reported reflections on use and experiences to investigate relationships between demographics, the number of chronic conditions, and virtual care use among older rural patients (≥65 years with at least one chronic condition) living in New South Wales, and their satisfaction with virtual care. Associations between categorical variables were assessed using chi-squared tests, and Kruskal-Wallis tests were used for continuous variables. Qualitative feedback was analysed thematically.

Leveraging cancer mutation data to inform the pathogenicity classification of germline missense variants.

Innovative and easy-to-implement strategies are needed to improve the pathogenicity assessment of rare germline missense variants. Somatic cancer driver mutations identified through large-scale tumor sequencing studies often impact genes that are also associated with rare Mendelian disorders. The use of cancer mutation data to aid in the interpretation of germline missense variants, regardless of whether the gene is associated with a hereditary cancer predisposition syndrome or a non-cancer-related developmental disorder, has not been systematically assessed.