Potassium KCa3.1 channel overexpression deteriorates functionality and availability of channels at the outer cellular membrane.

The engineered expression of K channels has been proposed as a potential treatment for epilepsy due to their exceptional ability to hyperpolarize neurons. A number of rodent models of gene therapy have yielded promising outcomes. However, the prevailing viral delivery methods for transgenes lack external control over expression, which may lead to the overproduction of K channel subunits and subsequent adverse effects.

Detection of clinically relevant variants in the gene below 10% allelic frequency: A multicenter study by ERIC, the European Research Initiative on CLL.

In chronic lymphocytic leukemia, the reliability of next-generation sequencing (NGS) to detect variants ≤10% allelic frequency (low-VAF) is debated. We tested the ability to detect 23 such variants in 41 different laboratories using their NGS method of choice. The sensitivity was 85.

Phytochemical Study of Ethanol Extract of L. and Evaluation of Its Antimicrobial Activity.

This study evaluates the antibacterial and antifungal effects of ethanol extracts from L. derived from freshly harvested plant biomass, including stems, leaves, flowers, and roots. The extract was analyzed using gas chromatography-mass spectrometry (GC-MS) to determine its antimicrobial activity against phytopathogenic bacteria and fungi.

Ca-permeable AMPA receptor-dependent silencing of neurons by KCa3.1 channels during epileptiform activity.

Ca-activated KCa3.1 channels are known to contribute to slow afterhyperpolarization in pyramidal neurons of several brain areas, while Ca-permeable AMPA receptors (CP-AMPARs) may provide a subthreshold source of Ca elevation in the cytoplasm. The functionality of these two types of channels has also been shown to be altered by epileptic disorders.