Publications by authors named "E B Lugli"
Background: Heart failure (HF) is strongly associated with inflammation. In pressure overload (PO)-induced HF, cardiac stress triggers adaptive immunity, ablation or inhibition of which blocks disease progression. We hypothesized that PO-HF might fulfill the often-used criteria of autoimmunity: if so, the associated adaptive immune response would be not only necessary but also sufficient to induce HF; it should also be possible to identify self-antigens driving the autoimmune response.
View Article and Find Full Text PDFNK cells are endowed with tumor killing ability, nevertheless most cancers impair NK cell functionality, and cell-based therapies have limited efficacy in solid tumors. How cancers render NK cell dysfunctional is unclear, and overcoming resistance is an important immune-therapeutic aim. Here, we identify autophagy as a central regulator of NK cell anti-tumor function.
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- Alloreactive T-cell responses can lead to graft-versus-host disease (GVHD) after allogeneic stem cell transplants, negatively impacting patient health by causing increased morbidity and mortality.
- However, these T-cells can also target remaining tumor cells in a beneficial way, contributing to the graft-versus-tumor effect (GVT) which helps prevent cancer relapse.
- The text discusses a method for identifying alloreactive naïve and memory T cells through co-culturing with antigen-presenting cells, using a CFSE dilution technique to track activation, which can then be analyzed for further research.
Article Synopsis
- CD8 T cells are crucial for controlling tumors but often become dysfunctional in the tumor environment; sodium chloride (NaCl) has been found to counteract this dysfunction and promote cancer regression.
- Supplementing NaCl during CD8 T cell culture enhances their activation and effectiveness while preserving key gene networks associated with T cell plasticity, leading to improved anti-tumor responses in mouse models.
- The research suggests that NaCl affects CD8 T cell function by boosting their glutamine consumption, which is essential for their overall effectiveness, indicating potential new strategies for enhancing cancer immunotherapy in humans.
Background: Urogenital schistosomiasis is caused by the parasitic trematode Schistosoma haematobium. Sensitive and specific point-of-care diagnostics are needed for elimination of this disease. Recombinase polymerase amplification (RPA) assays meet these criteria, and an assay to diagnose S.
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