Publications by authors named "E B Kostova"
Objective: To assess the effects of COVID-19 vaccines in women before or during pregnancy on SARS-CoV-2 infection-related, pregnancy, offspring and reactogenicity outcomes.
Design: Systematic review and meta-analysis.
Data Sources: Major databases between December 2019 and January 2023.
Article Synopsis
- Pregnant women infected with SARS-CoV-2 face increased risks, including preterm birth and higher rates of stillbirth or neonatal admissions, highlighting ongoing concerns even after the WHO declared an end to the COVID-19 pandemic in May 2023.
- A systematic review was performed to analyze the prevalence of early pregnancy loss in women with SARS-CoV-2 and compare these results to those of non-infected pregnant women.
- The review included various studies that reported pregnancy losses before 20 weeks, as well as data on ectopic pregnancies and pregnancy terminations, ensuring a comprehensive examination of the impact of SARS-CoV-2 on early pregnancy outcomes.
Infections with certain pathogens can lead to perinatal complications. Several infections have been also associated with an increased likelihood of miscarriage. This manuscript discusses these infections, their modes of transmission, the evidence linking them to an increased risk of miscarriage, and whether prevention or treatment strategies are available.
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- - The review investigates the effectiveness and safety of statins in women with polycystic ovary syndrome (PCOS) who are not trying to conceive, focusing on possible benefits like lowering testosterone levels and improving menstrual regularity.
- - The authors analyzed randomized controlled trials (RCTs), comparing statin treatments against placebos or other agents, by collecting data on menstrual regularity, ovulation, and other factors like acne and hirsutism.
- - Six RCTs involving a total of 396 women were included, with varying treatment durations, and the analysis was conducted using standard Cochrane methods to evaluate the certainty of the findings.
Background: The number of frozen embryo transfers (FET) has increased dramatically over the past decade. Based on current evidence, there is no difference in pregnancy rates when natural cycle FET (NC-FET) is compared to artificial cycle FET (AC-FET) in subfertile women. However, NC-FET seems to be associated with lower risk of adverse obstetric and neonatal outcomes compared with AC-FET cycles.
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