Publications by authors named "E B Kalinina"
Background: Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous entity including patients with different phenotypes of near normal, normal, and supernormal left ventricular (LV) function.
Objectives: To assess the value of resting LV elastance (also known as force) with transthoracic echocardiography (TTE) to identify HFpEF phenotypes.
Methods: In a prospective, observational, multicenter study, 2380 HFpEF patients were recruited from July 2016 to May 2024.
Objective: To evaluate descriptive efficacy data, exploratory immunogenicity data, and safety follow-up through study completion from the global, phase 3 MATISSE (Maternal Immunization Study for Safety and Efficacy) maternal vaccination trial of bivalent respiratory syncytial virus (RSV) prefusion F protein vaccine (RSVpreF).
Methods: MATISSE was a phase 3, randomized, double-blinded, placebo-controlled trial. Healthy pregnant participants aged 49 years or younger at 24-36 weeks of gestation were randomized (1:1) to receive a single RSVpreF 120 micrograms or placebo dose.
Article Synopsis
- Optogenetics combines light and genetic techniques to control specific living cells, showing potential for treating conditions like epilepsy and Alzheimer's disease.
- Recent studies highlight astrocytes’ crucial role in Alzheimer's, affecting processes like amyloid clearance and neuroinflammation.
- A study using optogenetic stimulation on astrocytes demonstrated enhanced bioelectrical activity in neural networks, suggesting this approach could serve as a new treatment for Alzheimer's.
Article Synopsis
- Older adults and those with chronic health conditions are particularly vulnerable to severe RSV disease, prompting research into the vaccine RSVpreF for high-risk individuals aged 18-59.
- In a phase 3 trial, participants received either RSVpreF or a placebo, with safety and immunogenicity monitored through various endpoints, revealing no serious adverse effects tied to the vaccine.
- Results showed that RSVpreF was well tolerated and met efficacy benchmarks, indicating it could be effectively used to prevent RSV-related illnesses in younger high-risk populations, similar to findings in older adults.
Objective: Atrial cardiomyopathy is closely associated with atrial fibrillation (AF), and some patients exhibit no dysfunction at rest but demonstrate evident changes in left atrial (LA) function and LA volume during exercise. This study aimed to identify distinguishing signs during exercise stress echocardiography (ESE) among patients in sinus rhythm (SR), with and without history of paroxysmal/persistent AF (PAF).
Methods: A prospective cohort of 1055 patients in SR was enrolled across 12 centers.