[Analysis of polymorphism at nine nuclear genome DNA loci in maris].

Population genetic survey of the indigenous populations of the Marii El Republic, represented by the two major ethnographic groups of Maris, Meadow (five samples from Morkinsk, Orshansk, Semursk, Sovetsk, and Zvenigovsk districts) and Mountain (one sample from Gornomariisk district) Maris, was carried out. All Mari groups were examined at nine polymorphic DNA loci of nuclear genome, VNTR(PAH) (N = 422), STR(PAH) (N = 152), VNTR(ApoB) (N= 294), VNTR(DAT1) (N = 363), VNTR(eNOS) (N = 373), ACE (N = 412), IVS6aGATT (N = 513), D7S23(KM.19) (N = 494), and D7S8 (N = 366).

[Analysis of the DRD4 gene polymorphism in populations of Russia and neighboring countries].

Allele and genotype frequencies of the VNTR polymorphism in the third exon of human DRD4 gene were determined in 544 individuals living in Russia (Russians, Bashkirs, Tatars, and Mordovians) and in the neighboring countries (Kazakhs and Ukrainians). The data obtained were compared with the allele frequency distribution patterns reported for the populations of Eurasia. Similarly to other Eurasian populations, in our population samples R4 allele was prevalent (64 to 87%).

[Association study of NcoI and TaqI A dopamine receptor D2 gene polymorphism in opium addicts].

The N2/N2 (NcoI) genotype of DRD2 gene is shown to be a marker of resistance to opium addiction, the N1/N1 genotype being considered as a risk marker for the disorder. The N1 allele was associated with opium addiction in Russian patients aged 16 years and younger at drug using onset. In Tatars, an association was found between the N1 allele and a risk of opium addiction development over 16 years of age.

[Association of the hSERT and SLC6A4 polymorphic markers of the serotonin transporter gene with schizophrenia in different ethnic groups].

Insertion/deletion and VNTR polymorphisms of the serotonin transporter gene were tested for association with schizophrenia in patients varying in ethnicity. A difference in genetic predisposition was observed for continuous and shift-like schizophrenia forms, the former tending to be associated with genotype 12/12 in Tatars and L/L in Russians.

[VNTR polymorphisms of the serotonin transporter and dopamine transporter genes in male opiate addicts].

VNTR polymorphisms of the serotonin transporter (hSERT) and dopamine transporter (DAT1) gene were studied in male opiate addicts. Samples of ethnic Russians and ethnic Tatars did not differ in genotype and allele frequencies. Homozygosity at hSERT (especially 10/10) was associated with early opiate addiction, while genotype 12/10 proved to be protective.