Publications by authors named "E B Filippova"
Ovarian cancer (OC) develops asymptomatically and escapes diagnosis until advanced stages, the feature contributing to a higher mortality rate. New prospects of OC diagnosis and treatment have been opened in studies of the gene regulation mechanisms that involve long noncoding RNAs (lncRNAs) and identification of the lncRNA genes that are inhibited via methylation of the promoter region. A set of 122 samples of primary OC tumors was examined by methylation specific real-time PCR to assess the methylation level of the lncRNA genes PLUT, SNHG1, SNHG6, SNHG12, and TINCR.
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- The small nucleolar RNA host gene (SNHG) family may contribute to cancer development by creating long non-coding RNAs and affecting ribosome production and small nucleolar RNA formation.
- A study analyzing 122 ovarian cancer samples found significant increases in the methylation levels of five SNHG family lncRNA genes, linking these changes to factors like tumor progression and metastasis.
- Additionally, there was a notable co-methylation among four of these genes and predictions of their interactions with specific microRNAs, suggesting their collective role in ovarian cancer pathogenesis.
Our work aimed to evaluate and differentiate the role of ten lncRNA genes (, , , , , , , , , and ) in the development and progression of epithelial ovarian cancer (EOC). A representative set of clinical samples was used: 140 primary tumors from patients without and with metastases and 59 peritoneal metastases. Using MS-qPCR, we demonstrated an increase in methylation levels of all ten lncRNA genes in tumors compared to normal tissues ( < 0.
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- siRNAs face challenges as antiviral agents due to poor cell penetration and instability, which can be addressed using non-agglomerated aminopropylsilanol nanoparticles (NP) for delivery.
- The study focused on modifying siRNAs, specifically their nucleoside sequences, to create NP-siRNA nanocomplexes aimed at inhibiting the replication of the influenza A/H5N1 virus.
- Results showed significant viral suppression, with the most effective nanocomplexes achieving a 900-fold reduction in virus replication, suggesting that certain siRNA modifications enhance their potential as therapeutic agents.
[Immunological and neuroanatomic markers of the clinical dynamics of MCI and pre-MCI].
Zh Nevrol Psikhiatr Im S S Korsakova
September 2024
Objective: To study the relationship of the parameters of immunity and systemic inflammation with the structural magnetic resonance imaging (MRI) parameters in patients with mild cognitive impairment (MCI) and pre-MCI undergoing neurocognitive rehabilitation to search for candidate markers of its effectiveness.
Material And Methods: The main group included 49 patients, aged ≥60 years, with MCI and pre-MCI with memory impairment, who underwent a course of neurorehabilitation for 5 weeks. The control group included 19 volunteers of similar age with a total MoCA score of ≥25, who did not have cognitive impairment and immuno-inflammatory disorders.