Low 25-Hydroxyvitamin D Post-Kidney Transplant Is Associated with Increased Risk of BK Polyomavirus-Associated Nephropathy.

BK viremia (BKPyV-DNAemia) and nephropathy (BKPyVAN) are significant causes of morbidity and mortality in kidney transplant recipients (KTRs). Vitamin D supports immune function, yet low 25-hydroxyvitamin D [25(OH)D] is common among KTRs. The association between serum 25(OH)D, measured 61 days to 2 years post-transplant, and subsequent incident BKPyV-DNAemia and BKPyVAN was examined in KTRs without previous BKPyV-DNAemia or BKPyVAN, respectively.

Technology of Combined Identification of Macrophages and Collagen Fibers in Liver Samples.

Unlabelled: The importance of identifying pathological changes in the liver both in fundamental researches and in diagnostic practice dictates the necessity to have a convenient method of assessing functional condition of resident macrophages and connective tissue fibers. is to assess the technology of combined histo-immunohistochemical detection of collagen fibers of connective tissue and resident liver macrophages using aniline blue histological stain and available antibodies to the microglial marker, the Iba-1 protein.

Materials And Methods: Liver samples from adult rats (n=6) have been used in the study.

Kainate-Induced Reorganization the Dentate Gyrus of the Hippocampus Is Accompanied by Activation of Mitochondrial Fission in the Granular Layer Neurons.

The reorganization of the dentate gyrus of the hippocampus and changes in mitochondrial fission were evaluated using the kainate model of temporal lobe epilepsy. In 28 days after administration of 0.5 μg kainic acid, disturbances in the distribution of neuronal precursors in the subgranular zone of the hippocampus, thickening of the granular layer, and an increase in the content of synaptophysin in the molecular layer were detected.

[Age-related changes in the choroid plexus of the brain include focal fibrosis of its villi.].

The choroid plexus of the cerebral ventricles is a highly vascularized villous structure that produces cerebrospinal fluid, forms the blood-cerebrospinal fluid barrier and regulates the exchange of biologically active molecules between blood and cerebrospinal fluid. The purpose of the work was to study the distribution of collagen fibers in the choroid plexus and determine the presence of type IV collagen in their composition. To identify collagen fibers, preparations were stained with aniline blue; the localization of type IV collagen was determined by immunohistochemistry.

The role of macrocycles in supramolecular assembly with polymers.

Recently, supramolecular self-assembly has attracted the attention of researchers worldwide because it enables the creation of nanostructures with unique properties without additional costs. Spontaneous organization of molecules allows the design and development of new nanostructures that can interact with drugs and living cells and generate a response. Therefore, supramolecular structures have enormous potential and can be in demand in various fields of healthcare and ecology.