[Radiation-induced modification of human somatic cell chromosome sensitivity to the testing mutagenic exposure of bleomycin in vitro in lung cancer patients in delayed terms following Chernobyl accident].

By using modified "G2-bleomycin sensitivity assay" above background level of cytogenetic effect considered as a marker of hidden chromosome instability (HCI) has been investigated in 3 groups--liquidators of Chernobyl accident (occupational group 1), patients with lung cancer who denied conscious contact--with ionizing radiation (group of comparison), liquidators with lung cancer (occupational group 2). Significant interindividual variations of cytogenetic effects induced with bleomycin and the lack of positive correlation between background and above background frequencies of chromosome aberrations have been shown in all observed groups. It had been established that occupational group 2 was the most burdened group by expression of the above background cytogenetic effect and, accordingly, number of persons with HCI.

[Somatic chromosome mutagenesis in residents of Ukraine exposed to ionizing radiation in different periods after the Chernobyl accident].

The authors summarize results of 25-year selective cytogenetic monitoring of the priority groups in different periods after the Chernobyl accident. The increase in intensity of somatic chromosome mutagenesis in exposed individuals as a result of both targeted and non-targeted radiation-induced cytogenetic effects has been confirmed including delayed, transmissible, hidden chromosome instability and the bystander effect.

[The results of 14-year cytogenetic monitoring of priority follow-up groups of Chernobyl accident victims].

The paper presents the results of 14-year (1987-2000) random cytogenetic monitoring of the Ukraine's population exposed to radiation due to the Chernobyl Atomic Power Plant accident. Conventional, G-banding, and molecular (FISH-WCP) cytogenetic methods were used to examine groups of victims exposed to radiation of varying intensity (reconvalescents diagnosed as having acute radiation disease, liquidators, Chernobyl power plant staff, and persons who had lived in the radionuclide-polluted areas, etc.).

[The dynamic course of the mutation process in human peripheral blood lymphocytes under conditions of exposure to low levels of ionizing radiation].

In seven groups of children living in the areas contaminated by nuclides a significant cytogenetic effect has been detected. The degree of its expression (integral and specific markers) was similar and did not correlate with the density of contamination by radionuclides.

[The cytogenetic monitoring of the victims of the accident at the Chernobyl Atomic Electric Power Station].

The results of the cytogenetic monitoring of population groups that are critical with respect to the intensity of irradiation exposure (liquidators of the accident, including those who suffered from acute atomic disease) or to sensitivity of cell genome to irradiation (children living in zones with radioactive contamination) indicate a significant increase in the frequency of both chromosomal aberrations and markers of the irradiation effect in each of the groups and correlate with the ecologic situation in the regions studied.