Trajectory of peripheral inflammation during index ECT in association with clinical outcomes in treatment-resistant depression.

Background: Electroconvulsive therapy (ECT) is a highly efficacious intervention for severe and intractable depression. Evidence suggests ECT provokes an initial acute inflammatory response that subsequently decreases with repeated administration. However, relationships between inflammatory changes and clinical effects are unclear.

A cross-sectional exploration of cognitive ability across age via stacked ensembles.

Age-related changes in cognitive and biological processes mean that older adults show markedly lower performance on cognitive assessments than younger adults. Characterizing the precise nature of age-related differences in cognitive performance and whether they vary as a function of key demographic characteristics has been challenging due to small effect sizes, underpowered samples, and blunt analysis methods. In the present study, we address these issues by using a massive cross-sectional data set of approximately 750,000 English-speaking participants who completed at least one battery from the NeuroCognitive Performance Test.

Convergent Validity of Experimental Cognitive Tests in a Large Community Sample.

Experimental cognitive tests are designed to measure particular cognitive domains, although evidence supporting test validity is often limited. The Consortium for Neuropsychiatric Phenomics test battery administered 23 experimental and traditional neuropsychological tests to a large sample of community volunteers ( = 1,059) and patients with psychiatric diagnoses ( = 137), providing a unique opportunity to examine convergent validity with factor analysis. Traditional tests included subtests from the Wechsler and Delis-Kaplan batteries, while experimental tests included the Attention Networks Test, Balloon Analogue Risk Task, Delay Discounting Task, Remember-Know, Reversal Learning Task, Scene Recognition, Spatial and Verbal Capacity and Manipulation Tasks, Stop-Signal Task, and Task Switching.

Overturning Children's Misconceptions about Ruler Measurement: The Power of Disconfirming Evidence.

Children have persistent difficulty with foundational measurement concepts, which may be linked to the instruction they receive. Here, we focus on testing various ways to support their understanding that rulers comprise spatial interval units. We examined whether evidence-based learning tools-disconfirming evidence and/or structural alignment-enhance their understanding of ruler units.

The effects of gesture and action training on the retention of math equivalence.

Introduction: Hand gestures and actions-with-objects (hereafter 'actions') are both forms of movement that can promote learning. However, the two have unique affordances, which means that they have the potential to promote learning in different ways. Here we compare how children learn, and importantly retain, information after performing gestures, actions, or a combination of the two during instruction about mathematical equivalence.