Publications by authors named "E B Chernyaeva"
Recombination is one of the mechanisms of SARS-CoV-2 evolution along with the occurrence of point mutations, insertions, and deletions. Recently, recombinant variants of SARS-CoV-2 have been registered in different countries, and some of them have become circulating forms. In this work, we performed screening of SARS-CoV-2 genomic sequences to identify recombination events and co-infections with various strains of the SARS-CoV-2 virus detected in Russia from February 2020 to March 2022.
View Article and Find Full Text PDFAnalysis of genomic variability of pathogens associated with heightened public health concerns is an opportunity to track transmission routes of the disease and helps to develop more effective vaccines and specific diagnostic tests. We present the findings of a detailed genomic analysis of the genomic variability of the SARS-CoV-2 Omicron variant that spread in Russia between 8 December 2021 and 30 January 2022. We performed phylogenetic analysis of Omicron viral isolates collected in Moscow ( = 589) and downloaded from GISAID ( = 397), and identified that the BA.
View Article and Find Full Text PDFThe genetic makeup of a breed including its genetic differences from other breeds determines its appearance and characteristics, including economically important traits and resistance to pathologies. To date, many loci controlling significant phenotypes have been identified, which is successfully used in the world practice of marker-assisted selection to improve breed properties. The aim of this study was a comparative analysis of frequencies for known causative nucleotide substitutions, insertions and deletions associated with disease and economically important traits in Russian and foreign cattle breeds.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on a pathogen, particularly tuberculosis (TB), which poses significant public health challenges due to issues like drug resistance and difficulties with diagnostics and treatment predictions.
- Researchers analyzed 145 clinical strains (72 pulmonary TB and 73 extra-pulmonary TB) from Russia between 2007 and 2014 using whole-genome sequencing to identify mutations linked to drug resistance.
- The findings reveal distinct genetic substrains related to the different TB localizations, with extra-pulmonary TB strains showing higher drug resistance, particularly associated with Beijing lineage while HIV was linked to increased occurrences of extra-pulmonary TB.
First insight into the whole-genome sequence variations in Mycobacterium bovis BCG-1 (Russia) vaccine seed lots and their progeny clinical isolates from children with BCG-induced adverse events.
BMC Genomics
August 2020
Article Synopsis
- The study investigates the genetic variations in Bacille Calmette-Guérin (BCG) vaccine strains, specifically focusing on seed lots used in Russia and their descendants linked to BCG-related diseases in children.
- Through whole-genome sequencing, researchers compared seed lots 361, 367, and 368 with nine progeny isolates and identified specific genetic mutations that could influence vaccine efficacy and virulence.
- The findings suggest that while genetic variations exist, they did not compromise the stability or effectiveness of the BCG vaccine, indicating that changes accumulate during the vaccine's time in the human body.