Publications by authors named "E B Brittebo"
Concerns have been raised regarding the potential adverse health effects of the ubiquitous herbicide glyphosate. Here, we investigated long-term effects of developmental exposure to a glyphosate-based herbicide (GBH) by analyzing serum melatonin levels and cellular changes in the striatum of adult male rats (90 days old). Pregnant and lactating rats were exposed to 3% GBH (0.
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- - Glyphosate, a widely used herbicide, has been linked to neurotoxicity and behavioral changes in rats following exposure during development, leading to potential long-term effects on the nervous system.
- - A study using advanced mass spectrometry found significant alterations in peptide expression in the substantia nigra (SN) of adult rats exposed to glyphosate-based herbicide (GBH) during critical developmental stages, highlighting reductions in specific opioid-related peptides.
- - The findings indicate that perinatal GBH exposure results in decreased dynorphin expression and a change in neurodevelopmental processes, as evidenced by an increase in neural precursor cells in the hippocampus, suggesting lasting impacts on neurodevelopment and behavior.
Olfactory dysfunction is implicated in neurodegenerative disorders and typically manifests years before other symptoms. The cyanobacterial neurotoxin β-N-methylamino-L-alanine (BMAA) is suggested as a risk factor for neurodegenerative disease. Detection of BMAA in air filters has increased the concern that aerosolization may lead to human BMAA exposure through the air.
View Article and Find Full Text PDFβ-Methylamino-L-alanine (BMAA) is a non-proteinogenic amino acid that induces long-term cognitive deficits, as well as an increased neurodegeneration and intracellular fibril formation in the hippocampus of adult rodents following short-time neonatal exposure and in vervet monkey brain following long-term exposure. It has also been proposed to be involved in the etiology of neurodegenerative disease in humans. The aim of this study was to identify metabolic effects not related to excitotoxicity or oxidative stress in human neuroblastoma SH-SY5Y cells.
View Article and Find Full Text PDFObjectives: Epidemiological studies report associations between exposure to the high-volume chemical and endocrine disruptor bisphenol A (BPA) and cardiovascular disorders, but there is a lack of experimental studies addressing the mechanisms of action of BPA on the cardiovascular system. In the present study, effects on markers for cardiovascular function of exposure to BPA and fructose in vivo in rat cardiac tissues, and of BPA exposure in human cardiomyocytes in vitro, were investigated.
Materials: Juvenile female Fischer 344 rats were exposed to 5, 50, and 500 μg BPA/kg bodyweight/day in their drinking water from 5 to 15 weeks of age, in combination with 5% fructose.