Potential and Possible Therapeutic Effects of Melatonin on SARS-CoV-2 Infection.

The absence of effective drugs for COVID-19 prevention and treatment requires the search for new candidates among approved medicines. Fundamental studies and clinical observations allow us to approach an understanding of the mechanisms of damage and protection from exposure to SARS-CoV-2, to identify possible points of application for pharmacological interventions. In this review we presented studies on the anti-inflammatory, antioxidant, and immunotropic properties of melatonin.

[PSYCHOPHARMACOLOGY OF ANTIPARKINSONIAN DRUGS].

Parkinson's disease as an extrapyramidal pathology is accompanied by some non-motor symptoms (depression, cognitive disorders, and sleep disturbance), which are based on disturbances of nigrostriatal dopaminergic neurotransmission supplemented by disorganization of other neuromediator systems. Traditional antiparkinsonian drugs with different cellular mechanism of action are capable of restricting these symptoms in patients and on animal models, while exhibiting their own psychotropic activity. This circumstance should be taken into account in assessing the pharmacological activity profiles of drugs.

[PROTECTIVE ROLE OF MELATONIN IN ETIOLOGY AND COURSE OF PARKINSON'S DISEASE: EXPERIMENTAL EVIDENCE.].

Literature data about participation of melatonin - the main hormone of pineal gland - in the origin and course of Parkinson's disease are reviewed. On the cellular level, melatonin demonstrates neuroprotective activity based on the limitation of oxidative stress, inflammation, and degradation of dopamine in nervous tissue, the attenuation of mitochondrial dysfunction, and the accumulation of alpha-synuclein, which are observed in parkinsonian animals and human patients. Moreover, melatonin is capable of inducing some systemic changes that limit disorganization of circadian rhythm and insomnia.

A description of barriers and facilitators to childhood vaccinations in the military health system.

Purpose: To perform a literature review of barriers to and facilitators of parents' decisions to have their children vaccinated. Both differences and similarities between the civilian sector and the military health system (MHS) were explored.

Data Sources: Articles and documents were identified from the following databases: CINAHL, PubMed, Defense Technical Information Center (DTIC), ISI, and Google Scholar.

[Current concepts of the origin of circadian changes in the cardiovascular system under normal and pathological conditions].

The importance of circadian rhythms for the function of the cardiovascular system and its pharmacotherapy is discussed The central mechanisms regulating these rhythms at the level of suprachiasmatic hypothalamic nucleus and pineal gland are considered in conjunction with the approaches to modulating their activity for optimization of chronopharmnacotherapy of cardiovascular diseases.