Validating brain activity measures as reliable indicators of individual diagnostic group and genetically mediated sub-group membership Fragile X Syndrome.

Recent failures translating preclinical behavioral treatment effects to positive clinical trial results in humans with Fragile X Syndrome (FXS) support refocusing attention on biological pathways and associated measures, such as electroencephalography (EEG), with strong translational potential and small molecule target engagement. This study utilized guided machine learning to test promising translational EEG measures (resting power and auditory chirp oscillatory variables) in a large heterogeneous sample of individuals with FXS to identify best performing EEG variables for reliably separating individuals with FXS, and genetically-mediated subgroups within FXS, from typically developing controls. Best performing variables included resting relative frontal theta power, all combined posterior-head resting power bands, posterior peak alpha frequency (PAF), combined PAF across all measured regions, combined theta, alpha, and gamma power during the chirp, and all combined chirp oscillatory variables.

On the implementation of acollinearity in PET Monte Carlo simulations.

Acollinearity of annihilation photons (APA) introduces spatial blur in positron emission tomography (PET) imaging. This phenomenon increases proportionally with the scanner diameter and it has been shown to follow a Gaussian distribution. This last statement can be interpreted in two ways: the magnitude of the acollinearity angle, or the angular deviation of annihilation photons from perfect collinearity.

Devaluation of Attractive Alternatives: How Those With Poor Inhibitory Ability Preemptively Resist Temptation.

How do people resist in-the-moment temptation if they are poor at inhibiting their impulses? Theory on self-control suggests that people have a toolbox of strategies available to them that may be used to dampen temptations. Applying this to the goal of relationship maintenance, in two studies, we examined whether people motivated to maintain their romantic relationship but poor at inhibitory control would appraise an attractive alternative (AA) as less appealing prior to a face-to-face interaction. In Study 1 ( = 190), those with high motivation and low inhibitory control (measured with the Stroop) rated the AA as less appealing as compared with singles and those high in motivation and inhibitory control.

On Creating Deeper Relationship Bonds: Felt Understanding Enhances Relationship Identification.

Relational experiences play a critical role in shaping how individuals see themselves. In four studies (=945) using person-perception, longitudinal, and experimental designs, we demonstrate that feeling understood changes individuals' self-concept by increasing the centrality of a specific relationship (relationship identification). Study 1 showed that participants perceived an individual to be more identified with their relationship when their partner was high (vs.