Publications by authors named "E Arce"
Article Synopsis
- YAT2150 is a new antimalarial drug that shows promise for malaria treatment and diagnosis by increasing fluorescence upon entering cells and blocking key developmental stages in malaria pathogens.
- The drug's effective uptake mechanisms and favorable pharmacokinetics make it a strong candidate for enhancing transmission-blocking strategies, especially when used in conjunction with immunoliposome encapsulation to reduce toxicity.
- YAT2150 interacts preferentially with unstructured proteins in parasites, which may lead to decreased protein aggregation, a mechanism also seen with traditional antimalarial treatments, positioning it as a potential leader in innovative malaria therapies.
Thermal simulations have become increasingly popular in assessing energy efficiency and predicting thermal behaviors in various structures. Calibration of these simulations is essential for accurate predictions. A crucial aspect of this calibration involves investigating the influence of meteorological variables.
View Article and Find Full Text PDFEffect of the aggregated protein dye YAT2150 on parasite viability.
Antimicrob Agents Chemother
March 2024
Article Synopsis
- The current treatments for leishmaniasis face challenges like drug resistance, toxicity, and high costs, highlighting the need for new therapies with different mechanisms.
- Newly identified YAT2150 shows strong effectiveness against both stages of the leishmaniasis parasite and its potency increases significantly when encapsulated in liposomes.
- This compound is unique as it not only has notable activity against leishmaniasis but also impacts ATP levels, suggesting it could be a viable treatment option for patients with co-infections.
Systems engineering plays a key role in the naval sector, focusing on how to design, integrate, and manage complex systems throughout their life cycle; it is therefore difficult to conceive functional warships without it. To this end, specialized information systems for logistical support and the sustainability of material solutions are essential to ensure proper provisioning and to know the operational status of the frigate. However, based on an architecture composed of a set of logistics applications, this information system may require highly qualified operators with a deep knowledge of the behavior of onboard systems to manage it properly.
View Article and Find Full Text PDFBackground: By 2016, signs of emergence of Plasmodium falciparum resistance to artemisinin and partner drugs were detected in the Greater Mekong Subregion. Recently, the independent evolution of artemisinin resistance has also been reported in Africa and South America. This alarming scenario calls for the urgent development of new antimalarials with novel modes of action.
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