Comparison of health technology assessments for digital therapeutics in Germany, the United Kingdom and France.

Objective: Digital therapeutics (DTx) are promising technologies. However, current assessment and access frameworks, when they exist, are heterogeneous and fragmented. We analysed and compared health technology assessment (HTA) criteria for DTx across European countries that had assessed the same DTx products.

Mechanochemical Polyoxometalate Super-Reduction with Lithium Metal.

In this first systematic investigation of mechanochemical polyoxometalate (POM) reduction, (TBA)[PMoO] was reacted with equiv of lithium metal ( = 1-24) to generate products which were shown to be mixtures of electron-rich species. FTIR analysis revealed the lengthening/weakening of terminal Mo═O bonds with increasing levels of reduction, while EXAFS spectra indicated the onset of Mo-Mo bond formation at ∼ 8 and a significant structural change at > 12. Successive Mo reductions were monitored by XANES and XPS, and at = 24, results were consistent with the formation of at least one Mo-Mo bonded {Mo} triad together with Mo.

Amine-modified polyionic liquid supports enhance the efficacy of PdNPs for the catalytic hydrogenation of CO to formate.

Palladium nanoparticles stabilised by aniline modified polymer immobilised ionic liquid is a remarkably active catalyst for the hydrogenation of CO to formate; the initial TOF of 500 h is markedly higher than either unmodified catalyst or its benzylamine and ,-dimethylaniline modified counterparts and is among the highest to be reported for a PdNP-based catalyst.