Research progress on production and biomedical applications of Schizophyllan as a tailor-made polysaccharide: A review.

Schizophyllan (SPG) is a polysaccharide of Schizophyllum commune with a β-(1 → 3)-glucan backbone structure, which has been discussed in recent years for its extensive biomedical applications. Among the biological properties of this polysaccharide are anti-cancer, antioxidant, anti-inflammatory and strengthening of the immune system. Its unique triple helix structure offers various advantages as a carrier for genes or other biomolecules.

Tissue-engineered sub-urethral sling with muscle-derived cells for urethral sphincter regeneration in an animal model of stress urinary incontinence.

Background: Stress urinary incontinence (SUI) is a widespread condition affecting more than 200 million people worldwide. Common treatments for this condition include retropubic colposuspension, and pelvic sling methods, which use autologous grafts or synthetic materials to support the bladder neck and urethral sphincter. Although these treatments have a cure rate of over 80%, adverse effects and recurrence may still occur.

Utilization of RESOLV with polymer to produce prazosin hydrochloride nanoparticles and optimization of the process parameters.

In this study, rapid expansion of a supercritical solution into a Liquid Solvent (RESOLV) was used for the first time to produce pharmaceutical nanoparticles of Prazosin hydrochloride (PRH). The Taguchi method (robust design) was utilized to design the experiments and ensure obtaining the optimal process conditions. The pressure (15-25 MPa), temperature (308-328 K) and nozzle diameter (300-700 μm) effects on the morphology and size distribution of the resulting particles were also examined.