Searching for the maximal packing fraction of hard disks confined by a circular cavity through replica exchange/event-chain Monte Carlo.

We utilized a blend of replica exchange and event-chain Monte Carlo techniques to generate candidate configurations, aiming for a maximal packing fraction of hard disks within a circular enclosure. Our investigation encompassed systems comprising N particles, with N ranging from 300 to 720. Through our analysis, we identified 108 novel maximal packings, with some surpassing existing configurations by over 0.

Chronic MK-801 administration provokes persistent deficits in social memory in the prairie vole (Microtus ochrogaster): A potential animal model for social deficits of schizophrenia.

The prairie vole (Microtus ochrogaster) is a rodent species that has been used extensively to study biological aspects of human social bonding. Nevertheless, this species has not been studied in the context of modeling social deficits characteristic of schizophrenia. Building on studies in rodents that show that sub-chronic administration of an NMDA receptor antagonist induces persistent behavioral and neurological characteristics of schizophrenia, we administered MK-801 (0.

Massive replica exchange Monte Carlo algorithm: a tool to access high pressure thermodynamics of hard systems.

We have explored the idea of producing the equilibrium equation of state, i.e. the pressure as a function of packing fraction, βP(φ), of a confined system up to very high pressures to yield the configuration that leads to the maximum packing fraction.

Treatment preferences among Japanese women with dysmenorrhea: results from a discrete choice experiment study.

Purpose: To examine patient preferences for oral and intrauterine system treatments for dysmenorrhea in Japan.

Patients And Methods: A discrete choice experiment was conducted to assess the willingness to accept trade-offs among hypothetical treatment profiles. An internet-based survey was administered to women 18-49 years of age who self-reported a dysmenorrhea diagnosis or experienced dysmenorrhea at least once in the past 6 months (N=309).