Publications by authors named "E Alexa"
Controlling Listeria monocytogenes and its associated biofilms in the food industry requires various disinfection techniques, including physical, chemical, and biological treatments. Biocides, owing to their ease of use, cost-effectiveness, dissolvability in water, and efficacy against a wide range of microorganisms, are frequently selected options. Nonetheless, concerns have been raised about their efficacy in controlling L.
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- * The review aims to investigate how ESKAPEE pathogens develop multidrug resistance, their presence in various food sources and water, and the challenges faced in controlling their spread through the food production chain.
- * It emphasizes the necessity for broader surveillance programs and public campaigns to effectively address antimicrobial resistance in both healthcare and food-related settings, as focusing solely on healthcare could overlook critical issues.
Heavy metals occur naturally in the environment, and their concentration varies in soil across different regions. However, the presence of heavy metals may influence the antimicrobial resistance (AMR) in bacterial populations. Therefore, the objective of this study was to investigate and characterise the antimicrobial resistance profiles of Enterobacterales in soil and bovine milk filters from high and low zinc-containing regions in Ireland.
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- * A total of 20 resistant Enterobacterales strains were isolated, with the dominant species being Serratia fonticola, followed by other species such as Escherichia coli and Citrobacter freundii.
- * Whole genome sequencing revealed resistance genes in the isolated strains and identified genes responsible for zinc resistance and multidrug efflux pumps, suggesting a connection between AMR and environmental factors like zinc concentration.
Article Synopsis
- Silibinin (SIL) from Silybum marianum has beneficial effects but suffers from low stability and bioavailability, prompting the research into its derivatives, silibilin oleate (SIL-O) and silibilin linoleate (SIL-L), as prodrugs for better biomedical applications.
- Characterization techniques like DFT calculations and NMR confirmed the successful formation of SIL-O and SIL-L, showing they have lower drug-likeness scores than SIL but still a positive overall drug score with no severe side effects expected.
- While SIL-O showed no toxicity at low concentrations, SIL-L was more toxic at high doses, particularly affecting certain cell types and demonstrating a slight irritant effect; thus,