Publications by authors named "E Aisha Suleiman"
Modulation of immune responses to liposomal vaccines by intrastructural help.
Eur J Pharm Biopharm
November 2023
The encapsulation of HIV-unrelated T helper peptides into liposomal vaccines presenting trimers of the HIV-1 envelope glycoprotein (Env) on the surface (T helper liposomes) may recruit heterologous T cells to provide help for Env-specific B cells. This mechanism called intrastructural help can modulate the HIV-specific humoral immune response. In this study, we used cationic T helper liposomes to induce intrastructural help effects in a small animal model.
View Article and Find Full Text PDFCOVID-19 Vaccine Acceptance, Attitude, Hesitancy, and Its Associated Factors among Wolaita Sodo University Students: A Mixed-Method Study.
J Environ Public Health
June 2023
Background: Countries in the world have been experiencing the ongoing impact and spread of the coronavirus disease (COVID-19) virus pandemic. The health and financial burden of the pandemic has prompted the need for timely and effective vaccination to be considered as the best strategy for controlling disease transmission. However, vaccine acceptability remains an area of concern in developing countries like Ethiopia.
View Article and Find Full Text PDFArticle Synopsis
- Primary open-angle glaucoma (POAG) is a common cause of blindness, linked to increased intraocular pressure and damage to the optic nerve and retinal cells, making early detection crucial for preserving vision.
- Traditional diagnosis is challenging due to the disease's asymptomatic nature in its early stages, but recent research indicates that analyzing tear fluid (TF) for protein changes can provide valuable biomarkers.
- A new method using differential scanning fluorimetry (nanoDSF) identified distinct TF protein profiles in 311 patients, allowing for a 70% identification rate of POAG, while machine learning minimized false positives to 13.5%, revealing significant changes in specific proteins and ligands associated with glaucoma.
Functionalization of experimental HIV-1 virus-like particle vaccines with heterologous T helper epitopes (T helper VLPs) can modulate the humoral immune response via intrastructural help (ISH). Current advances in the conjugation of native-like HIV-1 envelope trimers (Env) onto liposomes and encapsulation of peptide epitopes into these nanoparticles renders this GMP-scalable liposomal platform a feasible alternative to VLP-based vaccines. In this study, we designed and analyzed customizable Env-conjugated T helper liposomes.
View Article and Find Full Text PDFBackground: Testicular cancer is a relatively rare form of cancer but curable. In Nigeria, late presentation hinders treatment due to limited resources for diagnosis and treatment. Testicular self-examination enables men to identify the presence of lumps and any abnormality in their testes.
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