Publications by authors named "E Aho"
Deciphering Perspectives: A European survey on clinical decision support tools for dementia and Alzheimer's disease.
Dement Geriatr Cogn Disord
February 2025
Introduction: Technological advancements like digital monitoring tools, disease modifying therapies and artificial intelligence have been shown to improve the clinical management of neurocognitive diseases like Alzheimer's disease (AD). To enhance implementation in daily practice, users' input is essential in the technology development process. This study aimed to determine clinician's perspective of clinical decision support systems (CDSS) in the management of dementia and AD.
View Article and Find Full Text PDFThe ChAdOx1 nCoV-19 vaccine has been in large-scale use during the COVID-19 pandemic. Limited efficacy compared to mRNA vaccines and certain potential side effects raise the question of whether anti-adenoviral vector antibodies influence immune responses against the vaccine. Complement activation by ChAdOx1 and leukocyte phagocytosis of ChAdOx1 in vitro were studied.
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- Age-related macular degeneration (AMD) is a common cause of vision loss among older adults, and current treatment options are limited.
- Researchers identified genetic factors contributing to AMD risk by analyzing data from 12,495 AMD cases and 461,686 controls, discovering four key protective haplotypes.
- The study suggests that lowering levels of the protein FHR-5 could enhance certain immune pathways and potentially serve as a strategy to prevent or treat AMD.
Article Synopsis
- - The paper highlights the increasing difficulty in maintaining access to both old and new antibiotics, leading to negative impacts on healthcare and a rise in antibiotic resistance due to the use of less effective alternatives.
- - It identifies four types of antibiotic unavailability—short-term shortages, long-term shortages, deregistrations, and lack of registration—explaining their causes, consequences, and potential solutions, supported by examples from Norway, Romania, and Ethiopia.
- - Understanding the specific type of antibiotic unavailability is crucial for finding effective solutions, as strategies like stockpiling may only be effective for certain circumstances and won't address every issue related to access.
Background: The advancement of diagnostic and therapeutic interventions in early Alzheimer's disease (AD) has demanded the economic evaluation of such interventions. Resource utilization and cost estimates in early AD and, more specifically, the amyloid-positive population are still lacking. We aimed to provide cost estimates in AD in relation to disease severity and compare these with the control population.
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