Publications by authors named "E Aghajanova"
Investigation of genetic instability in patients with Diabetes Mellitus type I, II and LADA using buccal micronucleus cytome assay.
Mutat Res Genet Toxicol Environ Mutagen
December 2024
Article Synopsis
- The pilot study focused on the presence of micronuclei (MN) and other nuclear abnormalities in oral mucosa cells from patients with type I, II, and LADA diabetes, comparing results to healthy individuals.
- Cytogenetic analysis indicated that diabetes patients had significantly higher levels of MN, particularly in type I and LADA groups, suggesting potential cytotoxic and genotoxic effects of the disease.
- There was a strong correlation found between MN levels, blood glucose concentration, and glycosylated hemoglobin, highlighting the impact of diabetes on cellular health.
In the period of increasing prevalence of metabolic disorders such as obesity and diabetes, healthcare professionals are facing significant challenges. Therefore, an accurate global assessment of insulin resistance is of utmost importance. Current medical research is focused on identifying an easily accessible and reproducible gold-standard surrogate marker for insulin resistance.
View Article and Find Full Text PDFPurpose: The objectives of the ongoing, Phase 3, open-label extension trial enliGHten are to assess the long-term safety and efficacy of weekly administered long-acting growth hormone lonapegsomatropin in children with growth hormone deficiency.
Methods: Eligible subjects completing a prior Phase 3 lonapegsomatropin parent trial (heiGHt or fliGHt) were invited to participate. All subjects were treated with lonapegsomatropin.