Publications by authors named "E Adejuyigbe"
Article Synopsis
- This study explored how maternal and fetal genetics, particularly the CYP2B6 gene, affect prenatal exposure to the HIV drug efavirenz.
- Researchers collected blood samples from 112 HIV-positive pregnant women and their 107 newborns to assess drug concentrations and genetic variations.
- Results showed significant correlations in efavirenz levels between mothers and newborns, with notable differences in drug concentration based on the mother's CYP2B6 genotype, indicating the need for more research into the implications of these genetic factors on drug exposure.
In this study, we investigated the combined influence of pregnancy and genetic polymorphisms on efavirenz pharmacokinetics in cervicovaginal fluid (CVF) of women receiving antiretroviral therapy. Women receiving efavirenz-containing antiretroviral therapy were recruited from two hospitals in Nigeria during 2017-2020. Sparse CVF and plasma samples were obtained during pregnancy to assess the possible association between drug concentration and CYP2B6 polymorphisms (stage I).
View Article and Find Full Text PDFIncidence of possible serious bacterial infection in young infants in the three high-burden countries of the Democratic Republic of the Congo, Kenya, and Nigeria: A secondary analysis of a large, multi-country, multi-centre clinical trial.
J Glob Health
February 2024
Background: Neonatal infections are a major public health concern worldwide, particularly in low- and middle-income countries, where most of the infection-related deaths in under-five children occur. Sub-Saharan Africa has the highest mortality rates, but there is a lack of data on the incidence of sepsis from this region, hindering efforts to improve child survival. We aimed to determine the incidence of possible serious bacterial infection (PSBI) in young infants in three high-burden countries in Africa.
View Article and Find Full Text PDFIntroduction: Antibiotic-resistant bacteria complicate treatment options in neonatal sepsis, especially in developing countries. This study determined the epidemiology and bacteriological characteristics of neonatal sepsis at a tertiary hospital, in southwest Nigeria.
Methods: This was a cross-sectional study from December 2017 to April 2019 among admitted babies with clinical neonatal sepsis.
Article Synopsis
- * It evaluates the incidence of sepsis and bacterial profiles in two groups: those receiving iKMC from birth and those receiving conventional care with delayed KMC.
- * Results show a significant reduction in suspected sepsis rates among neonates in the iKMC group, especially in those with lower birth weights, indicating that immediate care can enhance health outcomes for vulnerable infants.