Publications by authors named "E Adachi"
This study compared intestinal DNA phage dynamics and gut microbiota changes observed at the onset of coronavirus disease 2019 (COVID-19). The study participants included 19 healthy individuals and 19 patients with severe acute respiratory syndrome coronavirus 2 infection. Significant differences were observed in the diversity of the intestinal DNA virome after the onset of COVID-19 compared with that in healthy individuals.
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- This study investigates the molecular epidemiology of syphilis in Japanese men who have sex with men (MSM), focusing on the relationship between bacteremia and disease effects.
- Researchers analyzed whole blood samples from syphilis-positive MSM predominantly living with HIV in Tokyo between 2019 and 2022 using multi-locus sequence typing for genetic analysis.
- Findings show the presence of two main strains of Treponema pallidum and a significant correlation between the detection of a specific genetic marker and elevated C-reactive protein levels, suggesting active infection.
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- The SOLAR study compared the effectiveness of a long-acting injection treatment (CAB + RPV LA) to a daily oral regimen (BIC/FTC/TAF) for HIV over 12 months, showing that the injection was just as effective in managing the virus.
- Out of 670 participants, those who switched to CAB + RPV LA reported significantly higher treatment satisfaction and better mental health outcomes compared to those who continued with BIC/FTC/TAF.
- 90% of participants preferred the long-acting injection, indicating a positive shift in perceptions regarding HIV treatment by reducing psychological challenges associated with daily medication regimens.
Familial and early recurrent pheochromocytoma in a child with a novel in-frame duplication variant of .
Clin Pediatr Endocrinol
October 2024
Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors often linked to underlying genetic variants. Genetic analysis can promote gene-adjusted, specific follow-up, and surveillance protocols for both patients and their families at risk. We report the case of a 7-yr-old boy with bilateral pheochromocytoma, which recurred a year after partial adrenalectomy.
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- PAI-1 is associated with blood clotting issues and endothelial dysfunction in severe COVID-19, and certain genetic variations can affect its expression.
- Clinical studies on COVID-19 patients found that while comorbidities didn’t correlate with specific genotypes, the 4G/5G polymorphism showed differences in fibrinolytic factors and IL-1β levels.
- The 4G4G genotype was linked to high PAI-1 levels and suppressed fibrinolysis, while inflammation-related endothelial dysfunction was a risk for those with the 5G5G genotype.