Publications by authors named "E Aarons"
Article Synopsis
- People with HIV are more likely to experience severe cases of mpox, including serious eye issues like keratitis and vision loss.
- Tecovirimat is the main antiviral treatment for severe mpox, but there's not much data on how well it works for eye-related cases.
- This report discusses a patient with advanced HIV who suffered from a serious eye infection due to mpox, needing a long treatment with tecovirimat because the virus lingered for almost 5 months.
Introduction: This study aimed to assess the role of the rs16969968 variant of nicotinic receptor alpha-5 subunit in regulating smoking behavior and nicotine intake in response to nicotine manipulations among dependent smokers in a naturalistic environment.
Aims And Methods: Sixty-nine adults (19 females) smoking 10 or more cigarettes per day (CPD) were asked to complete four 2-week study phases during which they smoked exclusively one of two types of Spectrum nicotine research cigarettes (FTC nicotine yield 0.8 and 1.
The optimum treatment for persistent infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is not known. Our case series, across 5 hospitals in 3 countries, describes 11 cases where persistent SARS-CoV-2 infection was successfully treated with prolonged courses (median, 10 days [range, 10-18 days]) of nirmatrelvir/ritonavir (Paxlovid). Most cases (9/11) had hematological malignancy and 10 (10/11) had received CD20-depleting therapy.
View Article and Find Full Text PDFThe management of coronavirus disease 2019 has become more complex due to the expansion of available therapies. The presence of severe acute respiratory syndrome coronavirus 2 variants and mutations further complicates treatment due to their differing susceptibilities to therapies. Here we outline the use of real-time whole genome sequencing to detect persistent infection, evaluate for mutations confering resistance to treatments, and guide treatment decisions.
View Article and Find Full Text PDFObjective: To characterise the clinical features of monkeypox infection in humans.
Design: Descriptive case series.
Setting: A regional high consequences infectious disease centre with associated primary and secondary care referrals, and affiliated sexual health centres in south London between May and July 2022.