Weather- and climate-driven power supply and demand time series for power and energy system analyses.

Reaching net-zero carbon emissions requires large shares of intermittent renewable energy and the electrification of end-use consumption, such as heating, making the future energy system highly dependent on weather variability and climate change. Weather exhibits fluctuations on temporal scales ranging from sub-hourly to yearly while climate variations occur on decadal scales. To investigate the intricate interplay between weather patterns, climate variations, and power systems, we developed a database of time series of wind and solar power generation, hydropower inflow, heating and cooling demand using an internally consistent modeling framework.

MCMC Methods for Parameter Estimation in ODE Systems for CAR-T Cell Cancer Therapy.

Chimeric antigen receptor (CAR)-T cell therapy represents a breakthrough in treating resistant hematologic cancers. It is based on genetically modifying T cells transferred from the patient or a donor. Although its implementation has increased over the last few years, CAR-T has many challenges to be addressed, for instance, the associated severe toxicities, such as cytokine release syndrome.

Minimal residual disease detection by next-generation sequencing in multiple myeloma: Promise and challenges for response-adapted therapy.

Assessment of minimal residual disease (MRD) is becoming a standard diagnostic tool for curable hematological malignancies such as chronic and acute myeloid leukemia. Multiple myeloma (MM) remains an incurable disease, as a major portion of patients even in complete response eventually relapse, suggesting that residual disease remains. Over the past decade, the treatment landscape of MM has radically changed with the introduction of new effective drugs and the availability of immunotherapy, including targeted antibodies and adoptive cell therapy.

The quantity-quality transition in the value of expanding wind and solar power generation.

Wind and solar photovoltaic generators are projected to play important roles in achieving a net-zero-carbon electricity system that meets current and future energy needs. Here, we show potential advantages of long-term site planning of wind and solar power plants in deeply decarbonized electricity systems using a macro-scale energy model. With weak carbon emission constraints and substantial amounts of flexible electricity sources on the grid (e.

Spatial constraints in large-scale expansion of wind power plants.

When wind turbines are arranged in clusters, their performance is mutually affected, and their energy generation is reduced relative to what it would be if they were widely separated. Land-area power densities of small wind farms can exceed 10 W/m, and wakes are several rotor diameters in length. In contrast, large-scale wind farms have an upper-limit power density in the order of 1 W/m and wakes that can extend several tens of kilometers.