Synergistic Antimicrobial Effect of Cold Atmospheric Plasma and Redox-Active Nanoparticles.

Cold argon plasma (CAP) and metal oxide nanoparticles are well known antimicrobial agents. In the current study, on an example of , a series of analyses was performed to assess the antibacterial action of the combination of these agents and to evaluate the possibility of using cerium oxide and cerium fluoride nanoparticles for a combined treatment of bacterial diseases. The joint effect of the combination of cold argon plasma and several metal oxide and fluoride nanoparticles (CeO, CeF, WO) was investigated on a model of colony growth on agar plates.

An Optical-Fiber-Based Key for Remote Authentication of Users and Optical Fiber Lines.

We have shown the opportunity to use the unique inhomogeneities of the internal structure of an optical fiber waveguide for remote authentication of users or an optic fiber line. Optical time domain reflectometry (OTDR) is demonstrated to be applicable to observing unclonable backscattered signal patterns at distances of tens of kilometers. The physical nature of the detected patterns was explained, and their characteristic spatial periods were investigated.

Triple Priority: TB/HIV Co-Infection and Treatment Outcomes among Key Populations in The Kyrgyz Republic: A National Cohort Study (2018-2022).

: Improving tuberculosis (TB) care in key populations is an operational research priority in the Kyrgyz Republic. Here, we describe the characteristics of TB/HIV co-infected individuals, their affiliations with key country-wide population groups, and their TB treatment outcomes. This was a cohort study using national programmatic data (2018-2022).

Discharge Outcomes of Severely Sick Patients Hospitalized with Multidrug-Resistant Tuberculosis, Comorbidities, and Serious Adverse Events in Kyrgyz Republic, 2020-2022.

Patients with multidrug-resistant tuberculosis (MDR-TB) who have comorbidities, complications, and experience serious adverse events (SAEs) are at substantial risk of having unfavorable hospital outcomes. We assessed characteristics and discharge outcomes of 138 MDR-TB patients hospitalized in the National Referral Center of Bishkek, Kyrgyz Republic, from January 2020 to August 2022. The main clinical characteristics included pulmonary complications (23%), malnutrition (33%), severe anemia (17%), diabetes mellitus (13%), viral hepatitis B and C (5%), and HIV infection (3%).

Use of cells in quercetin detection.

The possibility of detection and determination of flavonoids by using microbial cells was shown for the first time using the quercetin - Sp245 model system. The activity of the flavonoids quercetin, rutin and naringenin toward Sp245 was evaluated. It was found that when the quercetin concentration ranged from 50 to 100 μM, the number of bacterial cells decreased.