Stereospecific 7α-alkylation of 20-hydroxyecdysone in a lithium-ammonia solution.

The reaction of 20-hydroxyecdysone with methyl or ethyl iodide or allyl bromide in a lithium-ammonia solution results in stereospecific 7α-alkylation to give 7α-methyl-, 7α-ethyl-, and 7α-allyl-14-deoxy-Δ(8(14))-20-hydroxyecdysones, respectively. By catalytic hydrogenation (Pd-C/MeOH), the 7α-allyl derivative was converted to 7α-n-propyl-14-deoxy-Δ(8(14))-20-hydroxyecdysone.

Inhibitory effect of melatonin on 7, 12-dimethylbenz[a]anthracene-induced carcinogenesis of the uterine cervix and vagina in mice and mutagenesis in vitro.

Forty female CBA mice aged 3-4 months were exposed twice a week during 2 months to intravaginal applications of polyurethane sponges impregnated with 0.1% solution of 7,12-dimethylbenz[a]anthracene (DMBA) in triethyleneglycol. Three hours after each application the sponges were taken out.

[Effect of cycloferon on dissemination of Lewis lung carcinoma in mice and rhabdomyosarcoma ra-23 in rats].

Tumor growth and proliferative activity of tumor cells were suppressed and the number of pulmonary metastases in C57B16 mice decreased 3.3-fold following seven injections of cycloferon (100 mg/kg body) to induce interferon production. Injections were carried out 1-16 days after subcutaneous transplantation of Lewis lung carcinoma.

[Work conditions and morbidity of workers at plants manufacturing asbestos-technical products].

Significant role in the morbidity of asbestos-technical wares manufacturing mills workers play unfavorable conditions of labour (dusts of harmful chemicals, heavy manual operations and so on). The improvement of technology for the labour safety was recommended.

[Health status of workers in dye plants of instrument-making industries].

Up to now in dye-departments of instrument making industries there are no provisions for safe and harmless conditions that result in the increase of morbidity among workers. The prevailing forms in the pattern of diseases associated with temporary disability are those caused by adverse industrial factors. Health examinations identified symptoms of skin lesions, increased level of gynaecological pathology.