Publications by authors named "E A Weamer"
Article Synopsis
- - The study investigates the genetic factors behind neuropsychiatric symptoms common in Alzheimer's disease, specifically psychosis (AD+P) and affective disturbances like depression and anxiety (AD+A).
- - Using a large sample of nearly 10,000 Alzheimer's participants, researchers found genetic correlations between AD+P and AD+A, but these two conditions also showed distinct genetic profiles when compared to psychiatric disorders in non-AD individuals.
- - The findings highlight the need for integrating genetic data to develop better treatments, as both psychosis and affective symptoms in Alzheimer's have shared and differing genetic associations.
Article Synopsis
- - Psychotic symptoms, like delusions and hallucinations, impact about 50% of Alzheimer's disease (AD) patients, leading to worse outcomes, increased cognitive impairment, and more depressive symptoms compared to those without these symptoms.
- - A large genome-wide meta-analysis of over 12,000 AD patients revealed significant genetic variations linked to psychosis in AD, identifying two critical genetic loci and emphasizing the role of the APOE gene in risk factors.
- - The study found genetic correlations between AD with psychosis and factors like cognitive attainment and bipolar disorder, suggesting complex genetic interactions that affect susceptibility to both AD and associated psychotic symptoms.
Effects of Vitamin D Use on Outcomes of Psychotic Symptoms in Alzheimer Disease Patients.
Am J Geriatr Psychiatry
September 2019
Objective: To identify medications that may prevent psychosis in patients with Alzheimer disease (AD).
Methods: The authors compared the frequency of medication usage among patients with AD with or without psychosis symptoms (AD + P versus AD - P). The authors also conducted survival analysis on time to psychosis for patients with AD to identify drugs with beneficial effects.
A number of collaborators were not acknowledged for their contribution to this published article. The acknowledgements that were missing in this published article can now be found in the associated correction.
View Article and Find Full Text PDFPsychotic symptoms, defined as the occurrence of delusions or hallucinations, are frequent in Alzheimer disease (AD), affecting ~40 to 60% of individuals with AD (AD with psychosis (AD+P)). In comparison with AD subjects without psychosis, AD+P subjects have more rapid cognitive decline and poor outcomes. Prior studies have estimated the heritability of psychosis in AD at 61%, but the underlying genetic sources of this risk are not known.
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