Heterogenous CD8+ T Cell Maturation and 'Polarization' in Acute and Convalescent COVID-19 Patients.

Background: The adaptive antiviral immune response requires interaction between CD8+ T cells, dendritic cells, and Th1 cells for controlling SARS-CoV-2 infection, but the data regarding the role of CD8+ T cells in the acute phase of COVID-19 and post-COVID-19 syndrome are still limited.

Methods: . Peripheral blood samples collected from patients with acute COVID-19 ( 71), convalescent subjects bearing serum SARS-CoV-2 N-protein-specific IgG antibodies ( 51), and healthy volunteers with no detectable antibodies to any SARS-CoV-2 proteins (HC, 46) were analyzed using 10-color flow cytometry.

The imprint of star formation on stellar pulsations.

In the earliest phases of their evolution, stars gain mass through the acquisition of matter from their birth clouds. The widely accepted classical concept of early stellar evolution neglects the details of this accretion phase and assumes the formation of stars with large initial radii that contract gravitationally. In this picture, the common idea is that once the stars begin their fusion processes, they have forgotten their past.

The routing of medical evacuation of patients with ruptures of cerebral aneurysms from remote out-of-the-way rural area.

The patients with aneurysm subarachnoid hemorrhage (aSAH) living in remote, inaccessible, rural areas cannot be provided with urgent neurosurgical care on the spot. They require medical evacuation (ME) to neurosurgical hospital. The purpose of the study was to investigate effect of complex (multi-stage) and simple (one-stage) logistic scheme of ME of patients in acute period of aSAH on the outcome of the disease.

Alterations in B Cell and Follicular T-Helper Cell Subsets in Patients with Acute COVID-19 and COVID-19 Convalescents.

Background: Humoral immunity requires interaction between B cell and T follicular helper cells (Tfh) to produce effective immune response, but the data regarding a role of B cells and Tfh in SARS-CoV-2 defense are still sparse.

Methods: Blood samples from patients with acute COVID-19 ( = 64), convalescents patients who had specific IgG to SARS-CoV-2 N-protein ( = 55), and healthy donors with no detectable antibodies to any SARS-CoV-2 proteins (HC, = 44) were analyses by multicolor flow cytometry.

Results: Patients with acute COVID-19 showed decreased levels of memory B cells subsets and increased proportion plasma cell precursors compared to HC and COVID-19 convalescent patients, whereas for the latter the elevated numbers of virgin naïve, Bm2' and "Bm3+Bm4" was found if compared with HC.

[Cognitive dysfunction and content of inflammatory markers in patients after coronary artery bypass graft].

Aim: To study the relationship between the content of inflammatory biomarkers and cognitive function in patients after coronary artery bypass graft (CABG) performed in condition of artificial blood circulation (ABC) or open-heart surgery (OHS).

Material And Methods: Twenty-nine patients with ischemic heart disease who survived CABG, mean age 62.4±6.