Cytokine production in an model of SARS-CoV-2 lung infection.

Introduction: The mechanisms of the SARS-CoV-2-triggered complex alterations in immune cell activation and production of cytokines in lung tissue remain poorly understood, in part because of the limited use of adequate tissue models that simulate the structure and cell composition of the lung . We developed a novel model of SARS-CoV-2 infection of lung explants, that maintains the intact tissue composition and the viral load for up to 7-10 days. Using this model, we studied cytokine production during SARS-CoV-2 infection.

Peculiarities of Hemostasis and Proteomics in Patients With Acute Myocardial Infarction and Healthy Volunteers After SARS-CоV-2 Infection.

Aim: To identify the features of plasma, platelet hemostasis, and proteomic composition of the blood plasma in patients with acute myocardial infarction (AMI) and healthy volunteers after COVID-19.

Material And Methods: The study included patients with AMI who have recently had COVID-19 (AMI-post-COVID, n=56) and patients with AMI who have not recently had COVID-19 (AMI-control, n=141). Healthy volunteers constituted the control groups and were also divided into control-post-COVID (n=32) and control-control (n=71) groups.

[Brain-derived neurotrophic factor in the acute and early recovery period of ischemic stroke: the role of nocturnal hypoxemia].

Objective: To study the relationship between brain-derived neurotrophic factor (BDNF) and the severity of nocturnal hypoxemia in patients in the acute and early recovery period of ischemic stroke (IS).

Material And Methods: We enrolled 44 patients (27 men, 17 women), aged 18-85 years, in the acute phase of IS. At 3-month follow-up, 35 people were examined (21 men and 14 women).

Vacancy formation in a 1D chain of dust particles in a DC discharge.

The paper presents the first experimental observation of an atypical phenomena during self-organization of dust particles into a one-dimensional chain structure levitated vertically in the plasma of a DC glow discharge. Using a laser, the third (middle) dust particle was removed from the chain of five particles so that the positions of the remaining particles did not significantly change, and a vacancy occurred in the place of the removed particle. This state of the chain turned out to be very stable, which is confirmed by the observation of the subsequent exchange of places of the fourth and the fifth particles of the chain upon the action of the laser on the forth particle.