Publications by authors named "E A Van Os"

Article Synopsis
  • Chronic liver disease progresses to liver fibrosis and cirrhosis, posing a major global health risk, but existing models for studying these conditions are inadequate.
  • Researchers created advanced multicellular liver spheroid (MCLS) cultures from various liver cell types, achieving the formation of over 700 spheroids from a single mouse.
  • The MCLS cultures effectively mimic liver disease conditions, demonstrating responses like fibrosis and steatosis, making them valuable for testing potential anti-fatty liver drugs.
View Article and Find Full Text PDF

Liver sinusoidal endothelial cells have a gatekeeper function in liver homeostasis by permitting substrates from the bloodstream into the space of Disse and regulating hepatic stellate cell activation status. Maintenance of LSEC's highly specialized phenotype is crucial for liver homeostasis. During liver fibrosis and cirrhosis, LSEC phenotype and functions are lost by processes known as capillarization and LSEC dysfunction.

View Article and Find Full Text PDF

To date, there is no representative in vitro model for liver sinusoidal endothelial cells (LSECs), as primary LSECs dedifferentiate very fast in culture and no combination of cytokines or growth factors can induce an LSEC fate in (pluripotent stem cell (PSC)-derived) endothelial cells (ECs). Furthermore, the transcriptional programmes driving an LSEC fate have not yet been described. Here, we first present a computational workflow (CenTFinder) that can identify transcription factors (TFs) that are crucial for modulating pathways involved in cell lineage specification.

View Article and Find Full Text PDF

Background: Children placed under governmental supervision and staying in residential or foster care are more vulnerable to violence than children who live with their own families. One specific group of children staying in reception facilities under governmental supervision comprises unaccompanied refugee children who have fled to a host country without their parents.

Objective: This qualitative study explores the experiences of unaccompanied children with regard to violence in reception facilities in the Netherlands from the perspective of the children.

View Article and Find Full Text PDF

Best Interests of the Child (BIC) assessments provide migration authorities with behavioral information about which interests of the child could be taken into account before a decision is made on the request for a residence permit. This study provides insight into the quality and outcomes of BIC assessments with 16 unaccompanied children (15-18 years) and 11 accompanied children (4-16 years) who have recently arrived in the Netherlands and requested asylum (N = 27). The results suggest that BIC assessments provide relevant information that enables assessors to determine the best interests of recently arrived refugee children.

View Article and Find Full Text PDF