Publications by authors named "E A Timmermans"
Background: The adverse health effects of air pollution are well-established. Previous reviews have highlighted disparities in air pollution exposure between minoritized ethnic groups and majoritized ethnic groups. However, these reviews primarily focused on proximity to pollution sources rather than objectively measured concentrations.
View Article and Find Full Text PDFIn Vivo Effects of a GHR Synthesis Inhibitor During Prolonged Treatment in Dogs.
Pharmaceuticals (Basel)
October 2024
The activation of the growth hormone receptor (GHR) is a major determinant of body growth. Defective GHR signaling, as seen in human Laron dwarfism, resulted in low plasma IGF-1 concentrations and limited growth, but also marked absence in the development of breast cancer and type 2 diabetes. In vitro, we identified a small molecule (C#1) that inhibits the translation of GHR mRNA to receptor protein.
View Article and Find Full Text PDFBackground And Objectives: "Blue Zones" (BZs) are regions with exceptionally high numbers of longevous inhabitants. Several factors have been suggested to promote longevity in BZs, but the evidence generally does not meet scientific quality criteria. We aimed to characterize a municipality as a "relative BZ," satisfying 3 criteria: compared to other municipalities, more exceptionally longevous inhabitants, a higher life expectancy, and a more stable population.
View Article and Find Full Text PDFThe impact of environmental risk factors on chronic kidney disease (CKD) remains unclear. This systematic review aims to provide an overview of the literature on the association between the general external exposome and CKD development or progression. We searched MEDLINE and EMBASE for case-control or cohort studies, that investigated the association of the general external exposome with a change in eGFR or albuminuria, diagnosis or progression of CKD, or CKD-related mortality.
View Article and Find Full Text PDFArticle Synopsis
- - The study looked at how air pollution and green space affect cardiometabolic risk in Dutch children aged 5 to 17, using data from three large cohorts totaling 13,822 participants.
- - Researchers used statistical models to analyze the impact of air pollutants like nitrogen oxides (NO) and elemental carbon (EC) on cardiometabolic health, finding that higher levels of these pollutants were linked to increased health risks in one of the cohorts.
- - The study also explored the relationship between green space density and health, discovering that more green space in wider areas (2000 meters) was associated with lower health risk scores in two of the cohorts, while no significant relationship was found in smaller areas (500 meters).