Identifying meaningful aspects of health and concepts of interest for assessment in systemic lupus erythematosus: implications for digital clinical measure development.

Objectives: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with heterogeneous clinical manifestations which significantly impacts the daily lives of patients. Herein, we aimed to (i) investigate patients' perspectives on and experience with SLE; (ii) identify meaningful aspects of health (MAHs) and concepts of interest (COIs) in SLE that could be evaluated using digital clinical measures (DCMs); and (iii) identify target DCMs for their assessment.

Methods: A mixed-methods, multistep approach was deployed for (i) exploring patients' experience with SLE through a social media listening study and focused group discussions with patients; (ii) mapping patients' experiences to define MAHs and identify COIs measurable using DCMs; (iii) selecting DCMs for the target COIs; and (iv) identifying types of wearable sensors for measuring COIs in the patients.

Food-based indices for the assessment of nutritive value and environmental impact of meals and diets: A systematic review protocol.

Current food production and consumption practices are impacting both human and planetary health. Though these challenges are multifaceted, shifting to healthy dietary choices from sustainable food systems is one solution. Food-based labelling is a common public-health strategy aimed at influencing consumption practices, primarily displaying front-of-pack nutrition labelling to encourage healthier choices.

Global distribution and gap analysis of equine housing research: The findings so far and where to go next.

As a free-ranging, social species, the housing of horses () may limit their opportunity to display natural behaviour, compromising well-being. This review records and presents studies that have investigated horse housing design, evaluates the location and number of studies carried out to date, and reports the methods used to assess impact on equine well-being. A Boolean search was conducted in two databases: Web of Science and Scopus, filtered according to Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) protocol, resulting in 60 peer-reviewed papers for evaluation.

Enriched Molecular-Level View of Saline Wetland Soil Carbon by Sensitivity-Enhanced Solid-State NMR.

Soil organic matter (SOM) plays a major role in mitigating greenhouse gas emission and regulating earth's climate, carbon cycle, and biodiversity. Wetland soils account for one-third of all SOM; however, globally, coastal wetland soils are eroding faster due to increasing sea-level rise. Our understanding of carbon sequestration dynamics in wetlands lags behind that of upland soils.

Selective regulation of kinesin-5 function by β-tubulin carboxy-terminal tails.

The tubulin code hypothesis predicts that tubulin tails create programs for selective regulation of microtubule-binding proteins, including kinesin motors. However, the molecular mechanisms that determine selective regulation and their relevance in cells are poorly understood. We report selective regulation of budding yeast kinesin-5 motors by the β-tubulin tail.