[Influence of the antihypoxantic therapy on children with generalized peritonitis].

Aim: To improve the results of treatment of a widespread purulent peritonitis in children by optimizing fluid therapy includes the use of combined treatment: reamberin and remaxol.

Material And Methods: We studied 269 patients aged 1 to 15 years with a widespread purulent peritonitis treated at the children's surgical departments in Samara from 2001 to 2015. The study group included 179 children who used the optimized infusion therapy.

[GABA-NO interaction in the N. Accumbens during danger-induced inhibition of exploratory behavior].

In Sprague-Dawley rats by means of in vivo microdialysis combined with HPLC analysis, it was shown that presentation to rats during exploratory activity of a tone previously pared with footshock inhibited the exploration and prevented the exploration-induced increase in extracellular levels of citrulline (an NO co-product) in the medial n. accumbens. Intra-accumbal infusions of 20 μM bicuculline, a GABA(A)-receptor antagonist, firstly, partially restored the exploration-induced increase of extracellular citrulline levels in this brain area, which was inhibited by presentation of the tone, previously paired with foot-shock and, secondly, prevented the inhibition of exploratory behavior produced by this sound signal of danger.

[Synergetic activation of the nucleus accumbens nirtergic system by dopamine D1 and D2 receptor agonists].

In Sprague-Dawley rats by means in vivo microdialysis combined with HPLC analysis in was shown that an infusion into the medial n. accumbens of the dopamine D1 receptor agonist SKF-38393 (100 microM) caused a rise of extracellular levels of citrulline (an NO co-product) in this brain area (the average 139 +/- 3%), which was prevented by intraacumbal infusion of 0.5 mM 7-nitroindazole, a neuronal NO-synthase inhibitor.

[Stearic acid methyl ether: a new extracellular metabolite of the obligate methylotrophic bacterium Methylophilus quaylei].

Methyl esters of fatty acids, free fatty acids, and hydrocarbons were found in the culture liquid and in the cellular lipids of the obligate methylotrophic bacterium Methylophilus quaylei under optimal growth conditions and osmotic stress. The main extracellular hydrophobic metabolite was methyl stearate. Exogenous free fatty acids C16-C18 and their methyl esters stimulated the M.