Publications by authors named "E A Taĭgulov"

Article Synopsis
  • Scientists are working on developing drug delivery systems that target diseased tissues while minimizing side effects on healthy organs, with red blood cells (RBCs) showing potential as natural carriers due to their unique properties.
  • Autologous RBCs (derived from a patient’s own blood) are especially promising for drug delivery due to their safety, immunogenic compatibility, and biodegradability.
  • This review highlights advancements in encapsulating drugs into RBCs using osmotic methods, including clinical trial discussions and the need for automation in the production process to enhance the efficiency of targeted therapies.
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The authors studied the efficacy of directed transport of antibiotics in autologous blood shadows in the complex treatment of 73 patients with acute cholecystitis (the main group) in comparison with the traditional nonoperative treatment of 67 patients with the same disease (the control group). The directed transport of antibiotics in autologous blood shadows makes it possible to arrest adequately the clinico-laboratory manifestations of acute cholecystitis, thus preventing the development of infectious complications of the disease, shorten by 4.5 times the terms for arresting the clinico-laboratory manifestations of acute cholecystitis, and to optimize planned operative treatment.

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A high effectiveness of the use of target transport of antibiotics in the autological erythrocytic shadows in the complex of surgical treatment of acute cholecystitis in 65 elderly and senile patients when compared with that in use of the existing methods of conservative treatment was revealed. The method developed permits to create in the bile a high and prolonged antibiotic concentration, and as well to reduce 4.5-fold the time for cupping off acute cholecystitis, to increase the quality of examination, preoperative preparation and elective operative treatment of the patients.

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