Developing evidence for a national strategy for older adults in the criminal justice system: overview of the nominal group approach for this series of brief reports.

The number of people aged 50 and over entering the criminal justice system (CJS) in England and Wales is growing. This raises questions as to the suitability of the CJS to equitably accommodate individuals with complex illness or impairment, who might experience difficulties in cognitive function, frailty, and/or impaired mobility. Findings from the government, the third sector, and academic literature have highlighted the difficulties experienced by older adults in the CJS and those tasked with supporting them.

Structural Determinants of School Discipline: Examining State-Level Racial Bias and Neighborhood Opportunity.

Objective: Addressing the disproportionate use of school detentions and suspensions among Black youth is crucial for reducing educational and health disparities across the lifespan. Yet, few studies have explored external factors beyond school or individual characteristics as potential contributors to school discipline disparities, such as state-level racial bias and neighborhood opportunity.

Method: A subsample from the larger Adolescent Brain Cognitive Development (ABCD) Study® was used (M age at baseline = 9.

Differential impacts of germline and adult aggrecan knockout in PV+ neurons on perineuronal nets and PV+ neuronal function.

Perineuronal nets (PNNs) are a condensed form of extracellular matrix primarily found around parvalbumin-expressing (PV+) interneurons. The postnatal maturation of PV+ neurons is accompanied with the formation of PNNs and reduced plasticity. Alterations in PNN and PV+ neuron function have been described for mental disorders such as schizophrenia and autism.

Fast simulation of identity-by-descent segments.

The worst-case runtime complexity to simulate haplotype segments identical by descent (IBD) is quadratic in sample size. We propose two main techniques to reduce the compute time, both of which are motivated by coalescent and recombination processes. We provide mathematical results that explain why our algorithm should outperform a naive implementation with high probability.