[Continuous detoxication methods in acute kidney failure].

Recently, acute renal failure has often been managed with continuous extracorporeal detoxication of the blood. In this case detoxication unit worked for days or even weeks. The continuous detoxication (CD) has the advantages: no sharp homeostatic changes occur, blood detoxication covers the whole period of acute renal failure.

[The mathematical modelling of water-osmotic equilibrium during the performance of hemodialysis].

The model has been designed by the authors to prevent complications as a result of redistribution of liquid between cellular and extracellular spaces arising in the patient's body in the course of hemodialysis. Because movements of the liquid between the spaces depends on the osmolality gradient, two principal systems were identified: body water system and system of osmotically active substances. The latter incorporates sodium and potassium salts and urea.

[Changes in the picture of chronic diseases on long-term hemodialysis treatment].

New data published in the literature provided evidence for appearance of an unknown variant of amyloidosis recorded in patients with a 5-15-year history of hemodialysis. Such amyloidosis may result from high blood levels of beta-2-microglobulin unremovable at standard hemodialysis. Even highly permeable membranes which permit beta-2-microglobulin penetration fail to produce negative balance of this metabolite as the procedure stimulates leukocyte activity and, consequently, beta-2-microglobulin production.

[Beta 2-microglobulin kinetics during hemodialysis with different membranes].

Dialysers F6 (polysulphon membrane) and Altra Nova-170 (acetate cellulose-H membrane) were tested for effects on concentration of beta 2-microglobulin (beta-2 MG) in the course of hemodialysis. F6 produced a rise in beta-2 MG levels (50.0 +/- 7.