[Morphological and histochemical analysis of mucous membrane transformation of the artificial urinary bladder].

The performed morphologic study of transformation mechanisms of the intestinal reservoir mucous membrane using modern immunochemical and histochemical methods revealed three morphologic phases of enteric epithelium adaptation; reactive-inflammatory, compensatory-protective and atrophic. Enteric urinary reservoir preserves the cambial apparatus typical for the enteric phenotype with an inherent apoptosis activity and proliferation which confirms a low level of tumor transformation risk.

[Peculiarities of urinary bladder cancer tumor cells apoptosis response on neoadjuvant chemotherapy].

Induced apoptosis in urinary bladder cancer tumor cells of patients was studied using TUNEL reaction. It was shown that increase in induced apoptosis value had a definite correlation between corresponding features of tumor reaction as a response on Gemcitabine-Cisplatin neoadjuvant chemotherapy application. It was found that evaluation of induced apoptosis in urinary bladder cancer tumor cells using TUNEL method allows forecasting the effectiveness of chemotherapy on the cellular level in patients with this type of cancer.

[The cause of recurrent ureteral obstruction].

A clinical analysis was performed in 88 patients with ureteral obstruction. Causes having made the origination of recurrent ureteral obstruction occur were stricture (n = 59) and vesicoureteral reflux (VUR). Origination of the stricture of the ureter was caused by scar and sclerotic changes in its wall and neoimplanted ostium.

[The ureter's modeling during ureterocystoneostomy].

While complex examination of patients with megaureter in late stages it was established the afection in the first place of the ureter's muscular layer and the disorder of its contractice capacity. The causes of megaureter's occurrence were: obstruction of the ureter's intramural portion and vesico-ureteric reflux. Longitudinal resection of megaureter was conducted in 25 patients, the longitudinal ureter's fold formation--in 6, intraureteric plasty was done in 28.

[Aspects of etiology, pathogenesis and clinical course of the megaureter].

Complex examination was conducted in 408 patients with megaureter. Five stages of the disease are delineated. Greatest importance in the megaureter pathogenesis play the peristalsis disorder and the ureter's ectasia, the rise of intraluminal pressure, which are the compensational factors, directed on the urodynamics and renal function support.